Epipen and Cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Cortef (hydrocortisone). Common drug interactions include influenza among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Cortef. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

On Jul, 06, 2026

85 people who take Epipen and Cortef together, and have interactions are studied.

What are the common drug interactions of Epipen and Cortef, by gender? *:

female:

Influenza
Urinary tract infection
Asthenia (weakness)
Back pain
Hospitalisation
Infection
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal distension

male:

Headache (pain in head)
Cough
Renal impairment (severely reduced kidney function)
Drug resistance (reduction in effectiveness of a drug)
Migraine (headache)
Prostate infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Asthenia (weakness)
Asthma
Blood pressure systolic increased

What are the common drug interactions of Epipen and Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Asthma
Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Influenza
Anaemia (lack of blood)
Cardiac disorder
Chest discomfort
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)

10-19:

Gallbladder operation
Hospitalisation
Kidney infection
Surgery

20-29:

Headache (pain in head)
Hereditary angioedema (recurrent episodes of severe swelling)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal distension
Arthralgia (joint pain)
Eye pain
Fatigue (feeling of tiredness)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Night sweats (sweating in night)

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Anxiety
Asthma
B-cell lymphoma (blood cancer affecting b cells)
Back pain
Blood pressure systolic increased
Blood sodium decreased
Bronchial disorder

50-59:

Erythema (redness of the skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Productive cough
Cough
Drug ineffective
Coma (state of unconsciousness lasting more than six hours)
Fall
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Subdural haemorrhage (bleeding between the skull and the surface of the brain)

60+:

Headache (pain in head)
Cough
Pain
Drug resistance (reduction in effectiveness of a drug)
Migraine (headache)
Prostate infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Asthenia (weakness)
Death
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Asthma: 16 people, 18.82%
Immunodeficiency Common Variable: 15 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 14.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 14.12%
Hereditary Angioedema (recurrent episodes of severe swelling): 10 people, 11.76%
Pain: 8 people, 9.41%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 9.41%
Hypersensitivity: 7 people, 8.24%

* Approximation only. Some reports may have incomplete information.

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