Epipen and Mesalamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Mesalamine (mesalamine). Common drug interactions include diarrhoea among females and defaecation urgency among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Mesalamine. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

29 people who take Epipen and Mesalamine together, and have interactions are studied.

Epipen and Mesalamine drug interactions.

What are the common drug interactions of Epipen and Mesalamine, by gender? *:

female:

Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Arthralgia (joint pain)
Frequent bowel movements
Haematochezia (passage of stools containing blood)
Nausea (feeling of having an urge to vomit)
Pain
Pregnancy
Alopecia (absence of hair from areas of the body)
Back pain

male:

Defaecation urgency (a sudden compelling urge to defecate)
Blood pressure decreased
Frequent bowel movements
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pyrexia (fever)
Amyloidosis (a tumour within which amyloid is produced)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease

What are the common drug interactions of Epipen and Mesalamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Haematochezia (passage of stools containing blood)
Frequent bowel movements
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pregnancy
Vomiting
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cushingoid (obesity and weakening of the muscles)
Disability

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Chronic kidney disease

60+:

Defaecation urgency (a sudden compelling urge to defecate)
Diarrhoea
Cough
Frequent bowel movements
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pyrexia (fever)
Amyloidosis (a tumour within which amyloid is produced)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.79%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 13.79%
Pain: 3 people, 10.34%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 10.34%
Hypersensitivity: 3 people, 10.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.34%
Stress And Anxiety: 2 people, 6.90%
Eye Allergy: 2 people, 6.90%
Blood Pressure Abnormal: 2 people, 6.90%
Cardiac Disorder: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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