Epipen and Metrocream drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Metrocream (metronidazole). Common drug interactions include blood triglycerides increased among females.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Metrocream. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Metrocream?

Metrocream has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 458 Metrocream users. Check the latest studies of Metrocream.

On Jul, 10, 2026

13 people who take Epipen and Metrocream together, and have interactions are studied.

Epipen and Metrocream drug interactions.

What are the common drug interactions of Epipen and Metrocream, by gender? *:

female:

Blood triglycerides increased
Burning sensation
Weight decreased
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Back pain
Bipolar disorder (mood disorder)

male:

n/a

What are the common drug interactions of Epipen and Metrocream, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Rash

60+:

Blood triglycerides increased
Burning sensation
Weight decreased
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Oedema (fluid collection in tissue)
Back pain
Bipolar disorder (mood disorder)
Bladder disorder
Cardiomegaly (increased size of heart than normal)
Dizziness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 46.15%
Rickets (softening of bones): 4 people, 30.77%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 4 people, 30.77%
Pain: 4 people, 30.77%
Neuropathy Peripheral (surface nerve damage): 4 people, 30.77%
Nail Disorder (disease of nail): 4 people, 30.77%
Hypersensitivity: 4 people, 30.77%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 30.77%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 30.77%
Burning Sensation: 4 people, 30.77%

* Approximation only. Some reports may have incomplete information.

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