Epipen and Nac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Nac (n - acetyl cysteine). Common drug interactions include epistaxis among females and chorioretinopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Nac. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Nac?

Nac has active ingredients of n - acetyl cysteine. eHealthMe is studying from 855 Nac users. Check the latest studies of Nac.



On Jul, 20, 2026

19 people who take Epipen and Nac together, and have interactions are studied.

Epipen and Nac drug interactions.

What are the common drug interactions of Epipen and Nac, by gender? *:

female:

  1. Epistaxis (bleed from the nose)
  2. Thrombosis (formation of a blood clot inside a blood vessel)
  3. Influenza
  4. Injection site erythema (redness at injection site)
  5. Asthma
  6. Injection site pain
  7. Arthralgia (joint pain)
  8. Back pain
  9. Cough
  10. Crepitations (noises are produced by the rubbing of parts one against the other)

male:

  1. Chorioretinopathy (collection of fluid under the retina that results in visual distortion)
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Sinusitis (inflammation of sinus)
  4. Upper respiratory tract infection
  5. Stress
  6. Abdominal distension
  7. Anaemia (lack of blood)
  8. Blood pressure increased
  9. Dizziness
  10. Fatigue (feeling of tiredness)

What are the common drug interactions of Epipen and Nac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Breast cancer
  2. Cardiac failure congestive
  3. Cataract (clouding of the lens inside the eye)
  4. Constipation
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Facial paralysis (loss of function of face muscle)
  7. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  8. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
  9. Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
  10. Neuropathy peripheral (surface nerve damage)

50-59:

n/a

60+:

  1. Arthralgia (joint pain)
  2. Asthma
  3. Muscle spasms (muscle contraction)
  4. Productive cough
  5. Rhinorrhoea (watery mucus discharge from the nose)
  6. Seasonal allergy (allergic condition due to certain season)
  7. Sinusitis (inflammation of sinus)
  8. Somnolence (a state of near-sleep, a strong desire for sleep)
  9. Tenderness (pain or discomfort when an affected area is touched)
  10. Upper respiratory tract infection

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 11 people, 57.89%
  2. Ill-Defined Disorder: 2 people, 10.53%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.53%
  4. Lung Disorder (lung disease): 2 people, 10.53%
  5. Vitamin D Decreased: 1 person, 5.26%
  6. Dyspnea (difficult or laboured breathing): 1 person, 5.26%
  7. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 5.26%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
  9. Fungal Test Positive: 1 person, 5.26%
  10. Fungal Infection: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and Nac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Epipen and Nac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epipen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine and n - acetyl cysteine (the active ingredients of Epipen and Nac, respectively), and Epipen and Nac (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: