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Epipen and Primrose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Primrose (evening primrose oil). Common drug interactions include aortic valve incompetence among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Primrose. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Primrose?

Primrose has active ingredients of evening primrose oil. It is often used in hair loss. eHealthMe is studying from 2,314 Primrose users. Check the latest studies of Primrose.

On Aug, 03, 2026

23 people who take Epipen and Primrose together, and have interactions are studied.

Epipen and Primrose drug interactions.

What are the common drug interactions of Epipen and Primrose, by gender? *:

female:

  1. Aortic valve incompetence
  2. Abdominal pain upper
  3. Angioedema (rapid swelling of the dermis)
  4. Ankle fracture
  5. Blood cholesterol increased
  6. Cardiac failure
  7. Corneal abrasion (loss of the surface of cornea)
  8. Corneal disorder
  9. Dehydration (dryness resulting from the removal of water)
  10. Depression

male:

  1. Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Epipen and Primrose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Depression
  2. Nausea (feeling of having an urge to vomit)
  3. Surgery
  4. Vomiting

30-39:

  1. Corneal abrasion (loss of the surface of cornea)
  2. Corneal disorder
  3. Dehydration (dryness resulting from the removal of water)
  4. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  5. Dry eye (lack of adequate tears)
  6. Dysarthria (speech disorder)
  7. Ear pain
  8. Eye pain
  9. Eye swelling
  10. Memory impairment

40-49:

n/a

50-59:

  1. Ankle fracture
  2. Fall

60+:

  1. Aortic valve incompetence
  2. Mitral valve incompetence (inefficient heart valve)
  3. Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
  4. Hyperhidrosis (abnormally increased sweating)
  5. Immunodeficiency
  6. Palpitations (feelings or sensations that your heart is pounding or racing)
  7. Panic attack
  8. Temperature intolerance (inability to go in temperature)
  9. Therapeutic response unexpected
  10. Thyrotoxic crisis (a life threatening condition due to excess secretion of thyroid hormone)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 65.22%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 39.13%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and Primrose?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Epipen and Primrose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Primrose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epipen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Primrose and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine and evening primrose oil (the active ingredients of Epipen and Primrose, respectively), and Epipen and Primrose (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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