Epipen and Robitussin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Robitussin (guaifenesin). Common drug interactions include pulmonary hypertension among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Robitussin. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

On Aug, 10, 2026

47 people who take Epipen and Robitussin together, and have interactions are studied.

Epipen and Robitussin drug interactions.

What are the common drug interactions of Epipen and Robitussin, by gender? *:

female:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection
Wheezing (a high-pitched whistling sound made while you breath)
Infusion site erythema (reddening of the skin at infusion site)
Stomatitis (inflammation of mucous membrane of mouth)
Swelling
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Abortion spontaneous (naturally occurring miscarriage)

male:

Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Corynebacterium infection (infection by corynebacterium (diphtheria))
Decreased appetite
Disease progression
Dizziness
Dysarthria (speech disorder)
Fall
Fatigue (feeling of tiredness)
Gait disturbance

What are the common drug interactions of Epipen and Robitussin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dyspnoea (difficult or laboured respiration)
Increased bronchial secretion
Pneumonia
Pyrexia (fever)
Anaesthesia
Bronchomalacia (bronchomalacia is caused by a deficiency in the cartilaginous rings)
Cough
Headache (pain in head)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Influenza

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Acute respiratory failure
Corynebacterium infection (infection by corynebacterium (diphtheria))
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Parainfluenzae virus infection
Pyrexia (fever)

30-39:

Decreased appetite
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

40-49:

Mood swings (an extreme or rapid change in mood)
Muscular weakness (muscle weakness)
Poor quality sleep
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection
Aggression
Decreased appetite
Fall
Gait disturbance
Hysterectomy

50-59:

Dizziness
Fatigue (feeling of tiredness)
Abdominal pain
Acute respiratory failure
Anaemia (lack of blood)
Anaemia of chronic disease
Aspartate aminotransferase increased
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Asthenia (weakness)
Clavicle fracture
Disease progression
Dyspnoea (difficult or laboured respiration)
Eye irritation

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 13 people, 27.66%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 19.15%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 6 people, 12.77%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 8.51%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 8.51%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 6.38%
Pain: 3 people, 6.38%
Hypersensitivity: 3 people, 6.38%
Cough: 3 people, 6.38%
Asthma: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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