Epipen and Zyflo cr drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Epipen (epinephrine) and Zyflo cr (zileuton). Common drug interactions include idiopathic urticaria among females and pneumonia among males.
The phase IV clinical study analyzes what interactions people have when they take Epipen and Zyflo cr. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.
What is Epipen?
Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.
What is Zyflo cr?
Zyflo cr has active ingredients of zileuton. It is often used in asthma. eHealthMe is studying from 184 Zyflo cr users. Check the latest studies of Zyflo cr.
13 people who take Epipen and Zyflo cr together, and have interactions are studied.

What are the common drug interactions of Epipen and Zyflo Cr, by gender? *:
female:
- Idiopathic urticaria (allergic reactions, presence of hives with unknown cause)
- Lymphadenopathy (disease or enlargement of lymph nodes)
- Nasal obstruction (blockage of nose)
- Oral candidiasis (fungal infection of mouth)
- Oropharyngeal pain
- Pyrexia (fever)
- Rhinitis allergic (inflammation of the nasal airways due to allergy)
- Rhinorrhoea (watery mucus discharge from the nose)
- Sputum discoloured
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
male:
- Pneumonia
- Upper respiratory tract infection
What are the common drug interactions of Epipen and Zyflo Cr, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Peripheral swelling
30-39:
n/a
40-49:
- Pruritus (severe itching of the skin)
- Renal cell carcinoma (a kidney cancer)
- Swelling
- Urticaria (rash of round, red welts on the skin that itch intensely)
- Wheezing (a high-pitched whistling sound made while you breath)
50-59:
n/a
60+:
n/a
What are the existing conditions these people have? *
- Asthma: 10 people, 76.92%
- Immunodeficiency Common Variable: 3 people, 23.08%
- Eye Pruritus (eye itching): 2 people, 15.38%
* Approximation only. Some reports may have incomplete information.
Do you take Epipen and Zyflo cr?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Epipen and Zyflo cr:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Epipen:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Zyflo cr:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Epipen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zyflo cr and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on epinephrine and zileuton (the active ingredients of Epipen and Zyflo cr, respectively), and Epipen and Zyflo cr (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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