Epival and Lantus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epival (divalproex sodium) and Lantus (insulin glargine recombinant). Common drug interactions include megacolon among females and diabetes mellitus inadequate control among males.

The phase IV clinical study analyzes what interactions people have when they take Epival and Lantus. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

36 people who take Epival and Lantus together, and have interactions are studied.

What are the common drug interactions of Epival and Lantus, by gender? *:

female:

Megacolon (a very dilated colon)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Intestinal obstruction
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
General physical health deterioration (weak health status)
Anxiety
Blood glucose decreased
Diarrhoea
Dizziness

male:

Diabetes mellitus inadequate control
Blood cholesterol increased
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Blood creatine phosphokinase increased
Constipation
Dehydration (dryness resulting from the removal of water)
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Hyperglycaemia (high blood sugar)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)

What are the common drug interactions of Epival and Lantus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood cholesterol increased
Blood creatine phosphokinase increased
Constipation
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Hyperglycaemia (high blood sugar)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

Megacolon (a very dilated colon)
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
Intestinal obstruction
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
General physical health deterioration (weak health status)
Anxiety
Diarrhoea
Dizziness
Gingival bleeding (bleeding gums)

60+:

Dyspnoea (difficult or laboured respiration)
Fall
Orthopnoea (shortness of breath (dyspnea) when lying down)
Pneumonia
Psychotic disorder
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Vomiting
Ankle fracture
Back pain
Blood glucose decreased

What are the existing conditions these people have? *

Schizoaffective Disorder (a mental disorder characterized by disordered thought): 25 people, 69.44%
Osteoporosis (bones weak and more likely to break): 4 people, 11.11%
Type 2 Diabetes: 2 people, 5.56%
Constipation: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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