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Epival and Pregabalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epival (divalproex sodium) and Pregabalin (pregabalin). Common drug interactions include abdominal discomfort among females and asthma among males.

The phase IV clinical study analyzes what interactions people have when they take Epival and Pregabalin. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,069 Pregabalin users. Check the latest studies of Pregabalin.

On Jul, 27, 2026

15 people who take Epival and Pregabalin together, and have interactions are studied.

Epival and Pregabalin drug interactions.

What are the common drug interactions of Epival and Pregabalin, by gender? *:

female:

  1. Abdominal discomfort
  2. Dizziness
  3. Dry mouth
  4. Micturition urgency (urgency to pass the urine)
  5. Nausea (feeling of having an urge to vomit)
  6. Oropharyngeal pain
  7. Vomiting
  8. Anticonvulsant drug level below therapeutic
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  10. Agitation (state of anxiety or nervous excitement)

male:

  1. Asthma
  2. Cough
  3. Cholecystitis acute (rapid infection of gallbladder)
  4. Confusional state
  5. Myalgia (muscle pain)
  6. Pneumonia
  7. Road traffic accident
  8. Tooth extraction
  9. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  10. Eosinophilia (eosinophil count in the peripheral blood exceeds)

What are the common drug interactions of Epival and Pregabalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Acute myocardial infarction (acute heart attack)
  2. Bacterial infection
  3. Cardiac arrest
  4. Cholecystitis acute (rapid infection of gallbladder)
  5. Confusional state
  6. Myalgia (muscle pain)
  7. Pneumonia
  8. Road traffic accident
  9. Tooth extraction
  10. Sudden death

60+:

n/a

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 2 people, 13.33%
  2. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 6.67%
  3. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 6.67%
  4. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Epival and Pregabalin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Epival and Pregabalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epival:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pregabalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epival and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pregabalin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium and pregabalin (the active ingredients of Epival and Pregabalin, respectively), and Epival and Pregabalin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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