Epival and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epival (divalproex sodium) and Tylenol (acetaminophen). Common drug interactions include dry mouth among females and general physical health deterioration among males.

The phase IV clinical study analyzes what interactions people have when they take Epival and Tylenol. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

74 people who take Epival and Tylenol together, and have interactions are studied.

What are the common drug interactions of Epival and Tylenol, by gender? *:

female:

Dry mouth
Dyspnoea (difficult or laboured respiration)
Metastatic neoplasm (spreadable cancer tumour)
Vomiting
Abdominal discomfort
Abdominal pain
Abscess (pus)
Alopecia (absence of hair from areas of the body)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anuria (failure of the kidneys to produce urine)

male:

General physical health deterioration (weak health status)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Body temperature decreased
Chills (felling of cold)
Confusional state
Injection site discomfort
Injection site erythema (redness at injection site)
Injection site pain
Intentional self-injury
Migraine (headache)

What are the common drug interactions of Epival and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

General physical health deterioration (weak health status)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Anxiety
Depressed mood
Irritability
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mood swings (an extreme or rapid change in mood)
Vomiting
Blood potassium decreased
Drug level increased

30-39:

Affective disorder (mental disorder)
Blood albumin decreased
Cerebral atrophy (decrement in size of brain)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Endocrine disorder (endocrine diseases are disorders of the endocrine system)
Eye swelling
Fall

40-49:

Pyrexia (fever)
Pneumonia
Malaise (a feeling of general discomfort or uneasiness)
Cough
Body temperature decreased
Chills (felling of cold)
Confusional state
Fatigue (feeling of tiredness)
Injection site discomfort
Injection site erythema (redness at injection site)

50-59:

Acetabulum fracture (socket of the hip joint- fracture)
Anuria (failure of the kidneys to produce urine)
Bradycardia (abnormally slow heart action)
Cough
Decreased appetite
Diarrhoea
Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Diverticulitis meckel's (pouch on the wall of the lower part of the intestine that is present at birth (congenital)
Drug ineffective
Dyspepsia (indigestion)

60+:

Lipase increased
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Drug ineffective
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Oxygen saturation decreased
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection
Acute myocardial infarction (acute heart attack)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Asthenia (weakness)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 11 people, 14.86%
Headache (pain in head): 9 people, 12.16%
Bipolar Disorder (mood disorder): 8 people, 10.81%
Migraine (headache): 7 people, 9.46%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 7 people, 9.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.46%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 6 people, 8.11%
Stress And Anxiety: 5 people, 6.76%
Sleep Disorder: 5 people, 6.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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