Epivir and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epivir (lamivudine) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include dyspnoea among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Epivir and Vicodin. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Epivir?

Epivir has active ingredients of lamivudine. It is often used in hiv infection. eHealthMe is studying from 16,870 Epivir users. Check the latest studies of Epivir.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 13, 2026

73 people who take Epivir and Vicodin together, and have interactions are studied.

What are the common drug interactions of Epivir and Vicodin, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fibula fracture
Osteoporosis (bones weak and more likely to break)
Anaemia (lack of blood)
Ankle fracture
Death
Difficulty in walking
Femur fracture
Hypoglycaemia (deficiency of glucose in the bloodstream)
Muscle spasms (muscle contraction)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)
Rib fracture
Anaemia (lack of blood)
Nephropathy (damage to or disease of a kidney)
Osteonecrosis (death of bone)
Vomiting

What are the common drug interactions of Epivir and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Rash
Renal failure (kidney dysfunction)

30-39:

Nausea (feeling of having an urge to vomit)
Vomiting
Respiratory distress (difficulty in breathing)
Sweating increased (excess sweating)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Diarrhoea
Headache (pain in head)
Herpes zoster

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Chronic kidney disease
Hypoaesthesia (reduced sense of touch or sensation)
Arthralgia (joint pain)
Depression
Drug ineffective
Osteoporosis (bones weak and more likely to break)
Anaemia (lack of blood)

50-59:

Hyperthyroidism (over activity of the thyroid gland)
Laboratory test abnormal
Multiple fractures
Muscle cramp (painful sensation caused by muscle contraction)
Neck pain
Night sweats (sweating in night)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Respiratory rate increased (excess breathing rate/min)
Rib fracture

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Anxiety
Hand fracture
Renal failure (kidney dysfunction)
Rib fracture
Fracture
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Bone loss

What are the existing conditions these people have? *

Hiv Infection: 32 people, 43.84%
Depression: 5 people, 6.85%
Osteoporosis (bones weak and more likely to break): 4 people, 5.48%
Neuropathy Peripheral (surface nerve damage): 4 people, 5.48%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 5.48%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 5.48%
High Blood Pressure: 4 people, 5.48%
Aspergillosis (an infection caused by a fungus called aspergillus): 4 people, 5.48%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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