Eplerenone and Samsca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eplerenone (eplerenone) and Samsca (tolvaptan). Common drug interactions include haemoglobin decreased among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Eplerenone and Samsca. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

On Jul, 16, 2026

75 people who take Eplerenone and Samsca together, and have interactions are studied.

Eplerenone and Samsca drug interactions.

What are the common drug interactions of Eplerenone and Samsca, by gender? *:

female:

Haemoglobin decreased
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Oxygen saturation decreased
Pleural effusion (water on the lungs)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Aspartate aminotransferase increased
Blood pressure decreased

male:

Cardiac failure
Dehydration (dryness resulting from the removal of water)
Cardiomyopathy (weakening of the heart muscle)
Renal failure (kidney dysfunction)
Cardiac failure chronic
Ventricular fibrillation (abnormally irregular heart rhythm)
Blood creatine phosphokinase increased
Depression
Dyspnoea (difficult or laboured respiration)
Ileus (a painful obstruction of the ileum or other part of the intestine)

What are the common drug interactions of Eplerenone and Samsca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Dysphagia (a condition in which swallowing is difficult or painful)

20-29:

n/a

30-39:

n/a

40-49:

Hypotension (abnormally low blood pressure)
Right ventricular failure (right half of the heart fails to work)
Hypokalaemia (low potassium)
Diarrhoea
Cardiac failure
Brain natriuretic peptide increased
Headache (pain in head)
Dehydration (dryness resulting from the removal of water)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Abdominal distension

50-59:

Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)
Cardiac failure chronic
Dyspnoea (difficult or laboured respiration)
Liver disorder (liver diseases)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Pulmonary congestion (congestion in the lungs)
Renal impairment (severely reduced kidney function)
Altered state of consciousness (altered state of mind)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)

60+:

Cardiac failure
Blood pressure decreased
Depression
Haemoglobin decreased
Ileus (a painful obstruction of the ileum or other part of the intestine)
Renal failure (kidney dysfunction)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Oedema peripheral (superficial swelling)
Pyrexia (fever)

What are the existing conditions these people have? *

Cardiac Failure: 28 people, 37.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 19 people, 25.33%
Cardiac Failure Chronic: 18 people, 24.00%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 9 people, 12.00%
Cardiac Failure Congestive: 8 people, 10.67%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 9.33%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 8.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 8.00%
Right Ventricular Failure (right half of the heart fails to work): 5 people, 6.67%
Insomnia (sleeplessness): 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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