Esgic-plus and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esgic-plus (acetaminophen; butalbital; caffeine) and Cymbalta (duloxetine hydrochloride). Common drug interactions include sinusitis among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Esgic-plus and Cymbalta. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Esgic-plus?

Esgic-plus has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 269 Esgic-plus users. Check the latest studies of Esgic-plus.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

On Aug, 01, 2026

30 people who take Esgic-plus and Cymbalta together, and have interactions are studied.

Esgic-plus and Cymbalta drug interactions.

What are the common drug interactions of Esgic-Plus and Cymbalta, by gender? *:

female:

Sinusitis (inflammation of sinus)
Suicide attempt
Swollen tongue (swelling of tongue)
Abdominal discomfort
Accidental death
Adjustment disorder with depressed mood
Anoxic encephalopathy (brain damage due to lack of oxygen)
Aortic valve incompetence
Aphonia (inability to produce voice)
Arrhythmia (irregular heartbeat)

male:

Drug hypersensitivity

What are the common drug interactions of Esgic-Plus and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Aortic valve incompetence
Blood albumin decreased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Herpes simplex (herpes simplex is a common viral infection)
Irritability
Joint swelling
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nausea (feeling of having an urge to vomit)

40-49:

Adjustment disorder with depressed mood
Anoxic encephalopathy (brain damage due to lack of oxygen)
Aphonia (inability to produce voice)
Arrhythmia (irregular heartbeat)
Coma (state of unconsciousness lasting more than six hours)
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Ear infection
Haemorrhage (bleeding)
Hypotension (abnormally low blood pressure)

50-59:

Hospitalisation
Hypersensitivity
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Neuromyopathy (disease of both muscles and nerves)
Osteoporosis (bones weak and more likely to break)
Otitis media (inflammation of the middle ear)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Self-injurious ideation
Sinusitis (inflammation of sinus)

60+:

Accidental death
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 50.00%
Headache (pain in head): 3 people, 10.00%
Thyroid Diseases: 2 people, 6.67%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 6.67%
Quit Smoking: 2 people, 6.67%
Platelet Disorder: 2 people, 6.67%
Oedema Peripheral (superficial swelling): 2 people, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.67%
Fatigue (feeling of tiredness): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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