Esgic-plus and Stadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esgic-plus (acetaminophen; butalbital; caffeine) and Stadol (butorphanol tartrate). Common drug interactions include suicide attempt among females and dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Esgic-plus and Stadol. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Esgic-plus?

Esgic-plus has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 269 Esgic-plus users. Check the latest studies of Esgic-plus.

What is Stadol?

Stadol has active ingredients of butorphanol tartrate. It is often used in migraine. eHealthMe is studying from 5,546 Stadol users. Check the latest studies of Stadol.

On Jul, 28, 2026

16 people who take Esgic-plus and Stadol together, and have interactions are studied.

Esgic-plus and Stadol drug interactions.

What are the common drug interactions of Esgic-Plus and Stadol, by gender? *:

female:

Suicide attempt
Fatigue (feeling of tiredness)
Headache (pain in head)
Vomiting
Abdominal pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anger
Anxiety
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Confusion

male:

Dependence
Dependent personality disorder
Loss of consciousness
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Personality disorder

What are the common drug interactions of Esgic-Plus and Stadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Abdominal pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Confusion
Crying
Dehydration (dryness resulting from the removal of water)
Dependence
Depression
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

30-39:

Drug addiction

40-49:

Drug addiction
Drug dependence
Fatigue (feeling of tiredness)
Intentional self-injury
Social avoidant behaviour (avoiding social connection a personality disorder)
Suicide attempt
Anger
Confusional state
Dependence
Depression

50-59:

Dependence
Dependent personality disorder
Loss of consciousness
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Personality disorder

60+:

n/a

What are the existing conditions these people have? *

Headache (pain in head): 2 people, 12.50%
Sleep Disorder: 1 person, 6.25%
Pain: 1 person, 6.25%
Muscle Spasms (muscle contraction): 1 person, 6.25%
Cough: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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