Esgic and Detrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esgic (acetaminophen; butalbital; caffeine) and Detrol (tolterodine tartrate). Common drug interactions include cerebellar infarction among females and post-traumatic stress disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Esgic and Detrol. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

What is Detrol?

Detrol has active ingredients of tolterodine tartrate. It is often used in urge incontinence. eHealthMe is studying from 28,669 Detrol users. Check the latest studies of Detrol.

On Aug, 11, 2026

12 people who take Esgic and Detrol together, and have interactions are studied.

What are the common drug interactions of Esgic and Detrol, by gender? *:

female:

Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hospitalisation
Hyperthyroidism (over activity of the thyroid gland)
Intervertebral disc disorder (spinal disc disorder)
Overdose
Visual disturbance
Antinuclear antibody positive
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)

male:

Post-traumatic stress disorder
Facial bones fracture (bone fracture of face)
Suicidal ideation

What are the common drug interactions of Esgic and Detrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Rigors (an episode of shaking or exaggerated shivering)
Tetany (involuntary contraction of muscles)

40-49:

Blood triglycerides increased
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hospitalisation
Hyperthyroidism (over activity of the thyroid gland)
Intervertebral disc disorder (spinal disc disorder)
Overdose
Visual disturbance
Antinuclear antibody positive

50-59:

n/a

60+:

Back disorder
Back pain
Breast swelling
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Gastritis (inflammation of stomach)
Hypertrophy breast (increase in the volume of breast due to the enlargement of its component cells)
Inflammation
Neck pain
Pain

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 5 people, 41.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 25.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 25.00%
Stress And Anxiety: 2 people, 16.67%
Sleep Disorder: 2 people, 16.67%
Pain: 2 people, 16.67%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 16.67%
High Blood Cholesterol: 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Depression: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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