Esgic and Zithromax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esgic (acetaminophen; butalbital; caffeine) and Zithromax (azithromycin). Common drug interactions include abdominal distension among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Esgic and Zithromax. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

What is Zithromax?

Zithromax has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 35,525 Zithromax users. Check the latest studies of Zithromax.

On Jul, 15, 2026

24 people who take Esgic and Zithromax together, and have interactions are studied.

What are the common drug interactions of Esgic and Zithromax, by gender? *:

female:

Abdominal distension
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Antinuclear antibody positive
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Appetite disorder (abnormal eating habits)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Biliary tract disorder
Blood creatinine increased
Blood glucose increased

male:

Abdominal pain
Chest pain
Abdominal pain upper
Anxiety
Bezoar (mass found trapped in the gastrointestinal system)
Blood bilirubin increased
Blood bilirubin unconjugated increased
Diarrhoea
Drug maladministration
Fungal infection

What are the common drug interactions of Esgic and Zithromax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Chest pain
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Hydronephrosis (water inside the kidney)
Vomiting
Blood albumin decreased
Nausea (feeling of having an urge to vomit)
Splenomegaly (enlargement of spleen)
Abdominal pain upper

30-39:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiac murmur (an heart sound in valve abnormality)
Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Oedema lower limb (fluid collection in tissue of lower leg)
Blood sodium increased
Drug addiction
Oedema (fluid collection in tissue)

40-49:

Hyperventilation
Hypokalaemia (low potassium)
Irritable bowel syndrome
Low density lipoprotein increased (cholesterol increased in blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Melaena (the passage of black, tarry stools)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Anaemia (lack of blood)
Chest pressure sensation (feeling of pressure on chest)
Nerve root lesion (a localized change in nerve root tissue)
Pancreatitis (inflammation of pancreas)
Productive cough
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain upper
Back pain
Blood creatinine increased
Blood glucose increased

60+:

n/a

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 16.67%
Depression: 4 people, 16.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 16.67%
Headache (pain in head): 3 people, 12.50%
Stress And Anxiety: 2 people, 8.33%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 8.33%
Pain: 2 people, 8.33%
Osteoporosis (bones weak and more likely to break): 2 people, 8.33%
Oral Herpes (viral infection of mouth): 2 people, 8.33%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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