Esidrix and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esidrix (hydrochlorothiazide) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include general physical health deterioration among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Esidrix and Spiriva. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Esidrix?

Esidrix has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 1,846 Esidrix users. Check the latest studies of Esidrix.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

On Jul, 20, 2026

71 people who take Esidrix and Spiriva together, and have interactions are studied.

What are the common drug interactions of Esidrix and Spiriva, by gender? *:

female:

General physical health deterioration (weak health status)
Haematuria (presence of blood in urine)
Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Clostridium test positive
Constipation
Fatigue (feeling of tiredness)
Blood creatinine increased
Blood urea increased
Dental caries
Depressed level of consciousness

male:

Febrile neutropenia (fever with reduced white blood cells)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Sepsis (a severe blood infection that can lead to organ failure and death)
Acute myocardial infarction (acute heart attack)
Pneumonia
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fatigue (feeling of tiredness)
Neutropenia (an abnormally low number of neutrophils)
Oesophageal haemorrhage (bleeding from oesophagus)
Overdose

What are the common drug interactions of Esidrix and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaphylactic reaction (serious allergic reaction)

50-59:

Infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cough
Death
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Right ventricular failure (right half of the heart fails to work)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

General physical health deterioration (weak health status)
Fatigue (feeling of tiredness)
Blood urea increased
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Dental caries
Depressed level of consciousness
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 11.27%

* Approximation only. Some reports may have incomplete information.

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