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Estarylla and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estarylla (ethinyl estradiol; norgestimate) and Aleve (naproxen sodium). Common drug interactions include migraine among females.

The phase IV clinical study analyzes what interactions people have when they take Estarylla and Aleve. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Estarylla?

Estarylla has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 594 Estarylla users. Check the latest studies of Estarylla.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 18, 2026

13 people who take Estarylla and Aleve together, and have interactions are studied.

Estarylla and Aleve drug interactions.

What are the common drug interactions of Estarylla and Aleve, by gender? *:

female:

  1. Migraine (headache)
  2. Nausea (feeling of having an urge to vomit)
  3. Stress
  4. Hypersensitivity
  5. Respiratory depression (respiration has a rate below 12 breaths)
  6. Suicidal ideation
  7. Abdominal pain upper
  8. Abnormal dreams
  9. Diarrhoea haemorrhagic (bloody diarrhoea)
  10. Disease recurrence

male:

n/a

What are the common drug interactions of Estarylla and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Haematochezia (passage of stools containing blood)
  2. Hypophagia (reduced food intake)
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Nausea (feeling of having an urge to vomit)
  5. Pyrexia (fever)
  6. Abdominal pain upper
  7. Diarrhoea haemorrhagic (bloody diarrhoea)

20-29:

n/a

30-39:

  1. Drug ineffective
  2. Stress
  3. Suicidal ideation
  4. Disease recurrence
  5. Drug specific antibody present
  6. Ear infection
  7. Eyelid margin crusting (crusting at the lid margins, generally worse on waking)
  8. Insomnia (sleeplessness)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Drowsiness: 9 people, 69.23%
  2. Thyroid Diseases: 1 person, 7.69%
  3. Stress And Anxiety: 1 person, 7.69%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
  5. Acne (skin problems that cause pimples): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Estarylla and Aleve?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Estarylla and Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Estarylla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Estarylla and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aleve and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate and naproxen sodium (the active ingredients of Estarylla and Aleve, respectively), and Estarylla and Aleve (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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