Estrace and Axid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estrace (estradiol) and Axid (nizatidine). Common drug interactions include dyspnoea among females.

The phase IV clinical study analyzes what interactions people have when they take Estrace and Axid. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Axid?

Axid has active ingredients of nizatidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 2,980 Axid users. Check the latest studies of Axid.

On Aug, 01, 2026

31 people who take Estrace and Axid together, and have interactions are studied.

What are the common drug interactions of Estrace and Axid, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Chest pain
Vision blurred
Arthralgia (joint pain)
Cardiac murmur (an heart sound in valve abnormality)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Pleural effusion (water on the lungs)
Abdominal pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea

male:

n/a

What are the common drug interactions of Estrace and Axid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cholera (infection of the small intestine caused by the bacterium vibrio cholerae)
Chondritis (inflammation of cartilage)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Foot fracture
Muscular weakness (muscle weakness)
Osteoporosis (bones weak and more likely to break)
Ventricular extrasystoles (premature cardiac contraction)
Vitamin d deficiency

20-29:

n/a

30-39:

Cardiac failure congestive
Dyspnoea exertional (breathlessness or shortness of breath)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Tricuspid valve incompetence (inefficient heart valve)
Cardiac murmur (an heart sound in valve abnormality)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Syncope (loss of consciousness with an inability to maintain postural tone)
Lung disorder (lung disease)

40-49:

Thinking abnormal
Blood glucose decreased
Colitis (inflammation of colon)
Pruritus (severe itching of the skin)
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Arteriosclerosis (thickening and hardening of arteries)
Biliary colic
Biliary tract disorder
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood creatine kinase low
Blood glucose increased
Blood potassium decreased
Calcinosis (calcium deposits in any soft tissue)
Chest pressure sensation (feeling of pressure on chest)

60+:

Abdominal pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Hypertension (high blood pressure)
Lethargy (tiredness)
Mouth haemorrhage (bleeding from mouth)
Pain in extremity
Pyrexia (fever)
Renal failure (kidney dysfunction)
Surgery
Vision blurred

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 4 people, 12.90%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 12.90%
Diabetes: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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