Etomidate and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Etomidate (etomidate) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include essential thrombocythaemia among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Etomidate and Zosyn. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Etomidate?

Etomidate has active ingredients of etomidate. eHealthMe is studying from 2,496 Etomidate users. Check the latest studies of Etomidate.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

64 people who take Etomidate and Zosyn together, and have interactions are studied.

What are the common drug interactions of Etomidate and Zosyn, by gender? *:

female:

Essential thrombocythaemia (chronic blood cancer)
Exposed bone in jaw
Haematoma (collection of blood outside the blood vessels)
Intervertebral disc disorder (spinal disc disorder)
Jaw fracture
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Loose tooth
Mastication disorder (disease of chewing food)
Meningioma (a diverse set of tumours arising from the meninges)
Mitral valve incompetence (inefficient heart valve)

male:

Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Alanine aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Cerebral infarction (less blood supply to brain resulting tissue damage)
Death
Pneumomediastinum (air is present in the mediastinum)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Renal failure (kidney dysfunction)

What are the common drug interactions of Etomidate and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bradycardia (abnormally slow heart action)
Acute respiratory distress syndrome
Agitation (state of anxiety or nervous excitement)
Back pain
Blood phosphorus decreased
Hyperglycaemia (high blood sugar)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Leukocytosis (increased white blood cells)

30-39:

Renal impairment (severely reduced kidney function)
Aortic valve disease
Blood creatinine increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardiac failure congestive
Cardiac valve disease (heart valve disease)
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)

40-49:

Anaemia (lack of blood)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Lacunar infarction (a type of stroke)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Anxiety
Emotional distress
Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess jaw (tooth abscess or root abscess)
Atelectasis (partial or complete collapse of the lung)
Back pain
Bacterial infection
Blood immunoglobulin g decreased
Bone deformity

60+:

Death
Hypotension (abnormally low blood pressure)
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Respiratory failure (inadequate gas exchange by the respiratory system)
Cardiac failure congestive
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Haematoma (collection of blood outside the blood vessels)
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 9.38%
High Blood Pressure: 6 people, 9.38%
Bone Disorder: 6 people, 9.38%
Sedation: 5 people, 7.81%
Pneumonia: 5 people, 7.81%
Fever: 5 people, 7.81%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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