Etoposide and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Etoposide (etoposide) and Medrol (methylprednisolone). Common drug interactions include oedema peripheral among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Etoposide and Medrol. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Etoposide?

Etoposide has active ingredients of etoposide. eHealthMe is studying from 77,815 Etoposide users. Check the latest studies of Etoposide.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

83 people who take Etoposide and Medrol together, and have interactions are studied.

What are the common drug interactions of Etoposide and Medrol, by gender? *:

female:

Oedema peripheral (superficial swelling)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Fall
Haematoma (collection of blood outside the blood vessels)
Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Vomiting
Pyrexia (fever)
Abdominal pain upper
Nausea (feeling of having an urge to vomit)

male:

Abdominal pain
Pancreatitis acute (sudden inflammation of pancreas)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Renal failure acute (rapid kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Alopecia (absence of hair from areas of the body)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood bilirubin increased
C-reactive protein increased

What are the common drug interactions of Etoposide and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Escherichia sepsis (bacterial infection by escherichia coli)
Febrile neutropenia (fever with reduced white blood cells)
Lung disorder (lung disease)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Pyelonephritis (inflammation of kidney caused by bacteria)
Renal failure (kidney dysfunction)
Sodium retention
Thrombocytopenia (decrease of platelets in blood)

20-29:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Febrile neutropenia (fever with reduced white blood cells)
Neoplasm malignant (cancer tumour)

30-39:

Aphthous ulcer (mouth ulcer)
Blood bilirubin increased
Brain compression
Brain death
Disease progression
Disease recurrence
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haemorrhage intracranial (bleeding within the skull)
Headache (pain in head)
Hodgkin's disease recurrent (cancer originating from white blood cells -recurrent)

40-49:

Abdominal pain
Pancreatitis acute (sudden inflammation of pancreas)
Rash pruritic (redness with itching)
Blood lactate dehydrogenase increased
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Constipation
Diarrhoea
Headache (pain in head)
Abdominal pain upper

50-59:

Activities of daily living impaired
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Acute respiratory distress syndrome
Alcohol abuse
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angioplasty
Anxiety
Aphasia (damage to the parts of the brain that control language)
Arteriosclerosis (thickening and hardening of arteries)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

60+:

C-reactive protein increased
Neutropenia (an abnormally low number of neutrophils)
Infective exacerbation of chronic obstructive airways disease (severe infective lung disease with chronic obstructive airways disease)
Thrombocytopenia (decrease of platelets in blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Constipation
Electrolyte imbalance
Nausea (feeling of having an urge to vomit)
Peripheral embolism (sudden interruption of blood flow to an organ or body part)

What are the existing conditions these people have? *

Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 28 people, 33.73%
High Blood Pressure: 13 people, 15.66%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 10 people, 12.05%
Lung Cancer - Small Cell (lung cancer): 9 people, 10.84%
High Blood Cholesterol: 9 people, 10.84%
Lung Cancer - Non-Small Cell (lung cancer): 8 people, 9.64%
Insomnia (sleeplessness): 8 people, 9.64%
Metastases To Bone (cancer spreads to bone): 6 people, 7.23%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 6 people, 7.23%
Neoplasm Malignant (cancer tumour): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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