Euthyrox and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Euthyrox (levothyroxine sodium) and Leflunomide (leflunomide). Common drug interactions include spinal compression fracture among females and lupus-like syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Euthyrox and Leflunomide. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Euthyrox?

Euthyrox has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,740 Euthyrox users. Check the latest studies of Euthyrox.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 11, 2026

36 people who take Euthyrox and Leflunomide together, and have interactions are studied.

Euthyrox and Leflunomide drug interactions.

What are the common drug interactions of Euthyrox and Leflunomide, by gender? *:

female:

Spinal compression fracture (fracture due to spinal compression on bone)
Arthralgia (joint pain)
Abdominal discomfort
Anxiety
Bone pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fungal skin infection
Gastritis (inflammation of stomach)
Hyperhidrosis (abnormally increased sweating)

male:

Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Pneumonia
Leukopenia (less number of white blood cells in blood)
Drug ineffective
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain

What are the common drug interactions of Euthyrox and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Diarrhoea
Fall
Head injury
Headache (pain in head)
Hypertension (high blood pressure)
Influenza
Loss of consciousness
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

40-49:

Anxiety
Depression
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Breast disorder
Drug ineffective
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Tooth disorder (tooth disease)

50-59:

Arthralgia (joint pain)
Blood cholesterol increased
Phlebitis (inflammation of the walls of a vein)
Post procedural haemorrhage (post procedural bleeding)
Psoriasis (immune-mediated disease that affects the skin)
Skin lesion
Teeth brittle (other half has a defect in the teeth)
Tooth extraction
Tooth loss
Varicose vein (veins that have become enlarged and tortuous)

60+:

Back disorder
Insomnia (sleeplessness)
Rash
Spinal compression fracture (fracture due to spinal compression on bone)
Drug ineffective
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myositis (inflammation of the muscles)
Pain
Pulmonary tuberculosis (lungs tuberculosis)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 16.67%
Thyroid Diseases: 2 people, 5.56%
Stress And Anxiety: 2 people, 5.56%
Sinusitis (inflammation of sinus): 2 people, 5.56%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 2 people, 5.56%
Neck Pain: 2 people, 5.56%
Multiple Allergies (allergy to multiple agents): 2 people, 5.56%
Irritable Bowel Syndrome: 2 people, 5.56%
Fungal Infection: 2 people, 5.56%
Diabetes: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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