Euthyrox and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Euthyrox (levothyroxine sodium) and Oxycodone (oxycodone hydrochloride). Common drug interactions include dry mouth among females and hyponatraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Euthyrox and Oxycodone. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Euthyrox?

Euthyrox has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,740 Euthyrox users. Check the latest studies of Euthyrox.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Jul, 12, 2026

86 people who take Euthyrox and Oxycodone together, and have interactions are studied.

Euthyrox and Oxycodone drug interactions.

What are the common drug interactions of Euthyrox and Oxycodone, by gender? *:

female:

Dry mouth
Dyspnoea (difficult or laboured respiration)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary tract infection
Weight decreased
Abdominal pain
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alopecia (absence of hair from areas of the body)
Blood creatinine increased

male:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Fatigue (feeling of tiredness)
Jaundice cholestatic
Mouth haemorrhage (bleeding from mouth)
Renal failure (kidney dysfunction)
Tooth disorder (tooth disease)
Vomiting
Abdominal pain
Abdominal pain upper
Adverse drug reaction

What are the common drug interactions of Euthyrox and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Constipation
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Depression
Diplopia (double vision)
Disturbance in attention

40-49:

Anaemia (lack of blood)
Balance disorder
Device occlusion
Enterococcal sepsis
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Memory impairment
Slow response to stimuli (slow response by nerves)
Speech disorder developmental
Subileus

50-59:

Umbilical granuloma (umbilical abnormality in neonates, causing inflammation and drainage)
Malaise (a feeling of general discomfort or uneasiness)
Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Abdominal pain
Lumbar vertebral fracture
Secondary adrenocortical insufficiency (inadequate secretion of acth by the pituitary gland)
Abdominal pain lower
Cellulitis (infection under the skin)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

60+:

Anaemia (lack of blood)
Thrombocytopenia (decrease of platelets in blood)
General physical health deterioration (weak health status)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Neoplasm progression (growth of tumour)
Balance disorder
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Overdose

What are the existing conditions these people have? *

Urinary Tract Infection: 8 people, 9.30%
High Blood Pressure: 7 people, 8.14%
Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 6.98%
Splenomegaly (enlargement of spleen): 6 people, 6.98%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 6.98%
Diffuse Large B-Cell Lymphoma Stage Iv (cancer of b cells, a type of white blood cell-stage iv): 6 people, 6.98%
Depression: 6 people, 6.98%
Constipation: 5 people, 5.81%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 5.81%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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