Evoxac and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Evoxac (cevimeline hydrochloride) and Methotrexate sodium (methotrexate sodium). Common drug interactions include alopecia among females.

The phase IV clinical study analyzes what interactions people have when they take Evoxac and Methotrexate sodium. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

On Jul, 15, 2026

16 people who take Evoxac and Methotrexate sodium together, and have interactions are studied.

Evoxac and Methotrexate sodium drug interactions.

What are the common drug interactions of Evoxac and Methotrexate Sodium, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Leukopenia (less number of white blood cells in blood)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anxiety
Cellulitis (infection under the skin)
Chest discomfort
Corneal epithelium defect (outer layer defect of cornea)
Corneal perforation (small hole in a cornea)
Dizziness
Dyspnoea (difficult or laboured respiration)

male:

n/a

What are the common drug interactions of Evoxac and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Cellulitis (infection under the skin)
Chest discomfort
Corneal epithelium defect (outer layer defect of cornea)
Corneal perforation (small hole in a cornea)
Dizziness
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

Alopecia (absence of hair from areas of the body)
Leukopenia (less number of white blood cells in blood)
Therapeutic response unexpected
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Trichorrhexis (a condition in which the hairs break)
Vertigo
White blood cell count decreased
Anxiety

What are the existing conditions these people have? *

Dry Eyes (lack of adequate tears): 6 people, 37.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 18.75%
Joint Pain: 3 people, 18.75%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 12.50%
Insomnia (sleeplessness): 2 people, 12.50%
High Blood Pressure: 2 people, 12.50%
Ulcerative Keratitis (ulcerative inflammation of the cornea): 1 person, 6.25%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.25%
Conjunctivitis Viral (infection of conjunctiva by virus): 1 person, 6.25%
Corneal Abrasion (loss of the surface of cornea): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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