Exalgo and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exalgo (hydromorphone hydrochloride) and Oxycodone (oxycodone hydrochloride). Common drug interactions include impaired driving ability among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Exalgo and Oxycodone. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Exalgo?

Exalgo has active ingredients of hydromorphone hydrochloride. It is often used in chronic pain. eHealthMe is studying from 9,847 Exalgo users. Check the latest studies of Exalgo.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Jul, 17, 2026

100 people who take Exalgo and Oxycodone together, and have interactions are studied.

What are the common drug interactions of Exalgo and Oxycodone, by gender? *:

female:

Impaired driving ability
Palpitations (feelings or sensations that your heart is pounding or racing)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep disorder
Thermal burn (burn by heat)
Weight increased
Cough
Depression
Swelling
Asthenia (weakness)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Drug dependence
Acute respiratory failure
Anaemia (lack of blood)
Apnoea (suspension of external breathing)
Arthropathy
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the common drug interactions of Exalgo and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)

30-39:

Ankle fracture
Disease progression
Neuropathy peripheral (surface nerve damage)
Tibia fracture (fracture of lower leg bone)
Drug screen positive
Weight increased

40-49:

Cough
Abdominal pain
Arthralgia (joint pain)
Asthenia (weakness)
Butterfly rash
Collagen disorder (infection and weakness of collagen)
Depression
Discomfort
Dry skin
Dysuria (painful or difficult urination)

50-59:

Somnolence (a state of near-sleep, a strong desire for sleep)
Acute respiratory failure
Anaemia (lack of blood)
Arthropathy
Coagulopathy (blood's ability to clot is impaired)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug administration error
Enzyme level increased
Hepatitis acute
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

Fall
Balance disorder
Hand fracture
Head injury
Traumatic haemorrhage (a bleeding due to trauma)
Vomiting
Muscle spasms (muscle contraction)
Chest pain
Dry skin
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Constipation: 26 people, 26.00%
Depression: 23 people, 23.00%
Stress And Anxiety: 23 people, 23.00%
Muscle Spasms (muscle contraction): 22 people, 22.00%
High Blood Cholesterol: 18 people, 18.00%
High Blood Pressure: 18 people, 18.00%
Insomnia (sleeplessness): 17 people, 17.00%
Nausea (feeling of having an urge to vomit): 16 people, 16.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 15.00%
Diabetes: 14 people, 14.00%

* Approximation only. Some reports may have incomplete information.

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