Exalgo and Pregabalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exalgo (hydromorphone hydrochloride) and Pregabalin (pregabalin). Common drug interactions include abdominal pain among females and hallucination, auditory among males.

The phase IV clinical study analyzes what interactions people have when they take Exalgo and Pregabalin. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Exalgo?

Exalgo has active ingredients of hydromorphone hydrochloride. It is often used in chronic pain. eHealthMe is studying from 9,847 Exalgo users. Check the latest studies of Exalgo.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,071 Pregabalin users. Check the latest studies of Pregabalin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

14 people who take Exalgo and Pregabalin together, and have interactions are studied.

Exalgo and Pregabalin drug interactions.

What are the common drug interactions of Exalgo and Pregabalin, by gender? *:

female:

Abdominal pain
Constipation
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Malignant neoplasm progression (cancer tumour came back)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug dependence
Coma (state of unconsciousness lasting more than six hours)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)

male:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Vision blurred
Vomiting
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Acute hepatic failure
Death
Drug ineffective
Insomnia (sleeplessness)
Panic attack

What are the common drug interactions of Exalgo and Pregabalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Migraine (headache)
Optic atrophy (the loss of a proportion of optic disc nerve fibres)
Retinal dystrophy (progressive weakness and wasting of the retina)
Retinal pigmentation (pigmentation of retina)

40-49:

Abdominal pain
Constipation
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Malignant neoplasm progression (cancer tumour came back)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Abdominal pain upper
Anxiety
Back pain
Blood bilirubin increased
Blood lactate dehydrogenase increased

50-59:

Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Anxiety
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Hyperaesthesia
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Vision blurred
Vomiting
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

60+:

Somnolence (a state of near-sleep, a strong desire for sleep)
Coma (state of unconsciousness lasting more than six hours)
Pneumonia
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Constipation
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)

What are the existing conditions these people have? *

Pain: 9 people, 64.29%
Nausea (feeling of having an urge to vomit): 5 people, 35.71%
Stress And Anxiety: 3 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
Insomnia (sleeplessness): 3 people, 21.43%
Dyspnea (difficult or laboured breathing): 2 people, 14.29%
Abnormal Faeces (abnormal stool): 2 people, 14.29%
Irritable Bowel Syndrome: 2 people, 14.29%
Cystitis Interstitial (unknown cause characterized by bladder pain): 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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