Excedrin and Aciphex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Aciphex (rabeprazole sodium). Common drug interactions include stress fracture among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Aciphex. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

86 people who take Excedrin and Aciphex together, and have interactions are studied.

What are the common drug interactions of Excedrin and Aciphex, by gender? *:

female:

Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Cholecystitis chronic (long lasting infection of gallbladder)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Mobility decreased (ability to move is reduced)
Osteoporotic fracture (fracture due to weak bone)
Pathological fracture (broken bone caused by disease)
Renal injury (kidney injury)
Abdominal hernia

male:

Chronic kidney disease
Cerebral haemorrhage (bleeding within the brain)
Affect lability (emotional incontinence)
Aggression
Alcohol use
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Bone disorder
Confusional state

What are the common drug interactions of Excedrin and Aciphex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal discomfort
Abdominal distension
Abdominal pain upper
Abscess (pus)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)

30-39:

Pulmonary embolism (blockage of the main artery of the lung)
Arthralgia (joint pain)
Asthenia (weakness)
Bone disorder
Cholecystitis chronic (long lasting infection of gallbladder)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Drug ineffective
Dysstasia (difficulty in standing)

40-49:

Depression
Acute respiratory distress syndrome
Anaemia (lack of blood)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug ineffective
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Hip fracture
Insomnia (sleeplessness)
Lethargy (tiredness)

50-59:

Dysarthria (speech disorder)
Dysstasia (difficulty in standing)
Fracture delayed union (delayed cure of broken bone)
Haematoma (collection of blood outside the blood vessels)
Monoparesis (one limb is very weak, but not completely paralyzed)
Multiple injuries
Muscle injury
Neoplasm malignant (cancer tumour)
Osteolysis (dissolution of bone)
Renal failure (kidney dysfunction)

60+:

Chronic kidney disease
Drug ineffective
Cystitis (inflammation of the wall of the bladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug hypersensitivity
Femur fracture
Micturition urgency (urgency to pass the urine)
Rash macular (small, flat red spots)
Sleep disorder due to a general medical condition
Renal injury (kidney injury)

What are the existing conditions these people have? *

Thyroid Diseases: 14 people, 16.28%
Pain: 14 people, 16.28%
Osteoporosis (bones weak and more likely to break): 11 people, 12.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 12.79%
High Blood Pressure: 10 people, 11.63%
High Blood Cholesterol: 8 people, 9.30%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 8.14%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 7 people, 8.14%
Depression: 6 people, 6.98%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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