Excedrin and Cleocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Cleocin (clindamycin phosphate). Common drug interactions include chills among females and gastrooesophageal reflux disease among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Cleocin. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Cleocin?

Cleocin has active ingredients of clindamycin phosphate. It is often used in infection. eHealthMe is studying from 3,940 Cleocin users. Check the latest studies of Cleocin.

On Jul, 06, 2026

15 people who take Excedrin and Cleocin together, and have interactions are studied.

What are the common drug interactions of Excedrin and Cleocin, by gender? *:

female:

Chills (felling of cold)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Crying
Drug dependence
Drug ineffective
Eye disorder
Fall
Fatigue (feeling of tiredness)
Fear of disease
Feeling hot

male:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatitis acute
Alanine aminotransferase increased
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Atelectasis (partial or complete collapse of the lung)
Back pain
Bone loss

What are the common drug interactions of Excedrin and Cleocin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash
Respiratory alkalosis (elevated blood ph due to excess breathing)
Rib fracture
Self-injurious ideation
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)

30-39:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatitis acute
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Fear of disease
Hyperhidrosis (abnormally increased sweating)
Injury
Nausea (feeling of having an urge to vomit)

40-49:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Fall
Oral herpes (viral infection of mouth)
Chronic kidney disease

50-59:

Chills (felling of cold)
Fatigue (feeling of tiredness)
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Oral mucosal discolouration (change in colour of mucous membrane of mouth)
Pyrexia (fever)
Vulvovaginal erythema (redness of the skin of vulva and vagina)

60+:

Arrhythmia (irregular heartbeat)
Eye disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 33.33%
Pain: 5 people, 33.33%
Tooth Abscess (pus formation in tooth): 3 people, 20.00%
Indigestion: 2 people, 13.33%
Insomnia (sleeplessness): 2 people, 13.33%
Toothaches (tooth pain): 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Nausea (feeling of having an urge to vomit): 2 people, 13.33%
Type 2 Diabetes: 1 person, 6.67%
Eye Disorder: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and Cleocin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously