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Excedrin and Diclofenac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Diclofenac (diclofenac). Common drug interactions include depression among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Diclofenac. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Diclofenac?

Diclofenac has active ingredients of diclofenac. eHealthMe is studying from 41,319 Diclofenac users. Check the latest studies of Diclofenac.

On Jul, 15, 2026

62 people who take Excedrin and Diclofenac together, and have interactions are studied.

Excedrin and Diclofenac drug interactions.

What are the common drug interactions of Excedrin and Diclofenac, by gender? *:

female:

  1. Depression
  2. Dysgeusia (disorder of the sense of taste)
  3. Dysstasia (difficulty in standing)
  4. Ear discomfort
  5. Ear pain
  6. Enuresis (repeated inability to control urination)
  7. Epistaxis (bleed from the nose)
  8. Eye pain
  9. Facial bones fracture (bone fracture of face)
  10. Facial pain

male:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Nephrogenic anaemia (anaemia due to kidney disease)
  4. Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
  5. Cyst (a closed sac)
  6. Cystitis (inflammation of the wall of the bladder)
  7. Death
  8. Diarrhoea
  9. Fatigue (feeling of tiredness)
  10. Frequent bowel movements

What are the common drug interactions of Excedrin and Diclofenac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Chills (felling of cold)
  2. Diarrhoea
  3. Dizziness
  4. Fatigue (feeling of tiredness)
  5. Psoriasis (immune-mediated disease that affects the skin)
  6. Rash

30-39:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Chronic kidney disease
  4. Diarrhoea
  5. Gamma-glutamyltransferase increased
  6. Renal failure (kidney dysfunction)
  7. Anxiety
  8. Depression
  9. Fatigue (feeling of tiredness)
  10. Frequent bowel movements

40-49:

  1. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
  2. Fall
  3. Abdominal pain upper
  4. Arthralgia (joint pain)
  5. Back pain
  6. Balance disorder
  7. Cataract (clouding of the lens inside the eye)
  8. Chills (felling of cold)
  9. Contusion (a type of hematoma of tissue in which capillaries)
  10. Dehydration (dryness resulting from the removal of water)

50-59:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Renal impairment (severely reduced kidney function)
  4. Asthma
  5. Chest discomfort
  6. Dyspnoea (difficult or laboured respiration)
  7. Fall
  8. Infusion related reaction
  9. Ligament rupture (tear in ligament)
  10. Ligament sprain (ligament stretched)

60+:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Cystitis (inflammation of the wall of the bladder)
  4. Diarrhoea
  5. Dysstasia (difficulty in standing)
  6. Fatigue (feeling of tiredness)
  7. Gait disturbance
  8. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  9. General physical health deterioration (weak health status)
  10. Hypersensitivity

What are the existing conditions these people have? *

  1. Migraine (headache): 11 people, 17.74%
  2. Pain: 9 people, 14.52%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 14.52%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 14.52%
  5. Psoriasis (immune-mediated disease that affects the skin): 7 people, 11.29%
  6. Immunodeficiency Common Variable: 7 people, 11.29%
  7. High Blood Pressure: 5 people, 8.06%
  8. High Blood Cholesterol: 5 people, 8.06%
  9. Stress And Anxiety: 4 people, 6.45%
  10. Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and Diclofenac?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Excedrin and Diclofenac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Diclofenac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Excedrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diclofenac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine and diclofenac (the active ingredients of Excedrin and Diclofenac, respectively), and Excedrin and Diclofenac (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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