Excedrin and Levoxyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Levoxyl (levothyroxine sodium). Common drug interactions include aphasia among females and apathy among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Levoxyl. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

On Jul, 11, 2026

61 people who take Excedrin and Levoxyl together, and have interactions are studied.

What are the common drug interactions of Excedrin and Levoxyl, by gender? *:

female:

Aphasia (damage to the parts of the brain that control language)
Bladder disorder
Cataract (clouding of the lens inside the eye)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cystitis (inflammation of the wall of the bladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Difficulty in walking
Dyspnoea (difficult or laboured respiration)
Back pain
Insomnia (sleeplessness)

male:

Apathy
Fatigue (feeling of tiredness)
Eyelid margin crusting (crusting at the lid margins, generally worse on waking)
Intraocular pressure increased
Lacrimation increased
Nightmare (unpleasant dream)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Vision blurred
Hypersomnia (excessive daytime sleepiness (eds))

What are the common drug interactions of Excedrin and Levoxyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Asthenia (weakness)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Back pain
Blood calcium increased
Bone disorder
Bone loss
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Calcium ionised increased

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Anxiety
Asthma
Blood cholesterol increased
Cold sweat
Cough
Depression
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Limb injury

40-49:

Back pain
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Hypersensitivity
Influenza
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Micturition urgency (urgency to pass the urine)
Nasopharyngitis (inflammation of the nasopharynx)
Neck pain

50-59:

Mouth ulceration (mouth ulcers)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Neck pain
Neuritis (inflammation of nerve)
Night sweats (sweating in night)
Oropharyngeal pain
Oropharyngeal plaque (hard deposit on oropharynx)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)

60+:

Insomnia (sleeplessness)
Arthralgia (joint pain)
Eye irritation
Hypersomnia (excessive daytime sleepiness (eds))
Laziness
Nausea (feeling of having an urge to vomit)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Throat irritation

What are the existing conditions these people have? *

Pain: 16 people, 26.23%
High Blood Cholesterol: 14 people, 22.95%
High Blood Pressure: 11 people, 18.03%
Depression: 9 people, 14.75%
Osteoporosis (bones weak and more likely to break): 7 people, 11.48%
Dyspnea (difficult or laboured breathing): 6 people, 9.84%
Stress And Anxiety: 6 people, 9.84%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 9.84%
Arthropod Sting (arthropod bite): 6 people, 9.84%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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