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Excedrin and Methylfolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Methylfolate (folic acid). Common drug interactions include weight decreased among females.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Methylfolate. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,017 Methylfolate users. Check the latest studies of Methylfolate.

On Jul, 07, 2026

20 people who take Excedrin and Methylfolate together, and have interactions are studied.

Excedrin and Methylfolate drug interactions.

What are the common drug interactions of Excedrin and Methylfolate, by gender? *:

female:

  1. Weight decreased
  2. Breast mass
  3. Influenza
  4. Infusion site mass
  5. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  6. Ear infection
  7. Eye infection
  8. Upper respiratory tract infection
  9. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  10. Chills (felling of cold)

male:

n/a

What are the common drug interactions of Excedrin and Methylfolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Haemorrhage (bleeding)
  2. Herpes zoster
  3. Muscle spasms (muscle contraction)
  4. Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
  5. Uterine pain

30-39:

  1. Anxiety
  2. Chills (felling of cold)
  3. Depression
  4. Dizziness
  5. Fatigue (feeling of tiredness)
  6. Hyperhidrosis (abnormally increased sweating)
  7. Irritability
  8. Mood swings (an extreme or rapid change in mood)
  9. Myalgia (muscle pain)
  10. Nausea (feeling of having an urge to vomit)

40-49:

  1. Breast mass
  2. Injection site pain
  3. Infusion site mass
  4. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  5. Sinusitis (inflammation of sinus)
  6. Ear infection
  7. Eye infection
  8. Upper respiratory tract infection
  9. Fungal infection
  10. Injection site mass

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 11 people, 55.00%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 15.00%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 15.00%
  4. Asthma: 2 people, 10.00%
  5. Migraine (headache): 1 person, 5.00%
  6. Depression: 1 person, 5.00%
  7. Birth Control: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and Methylfolate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Excedrin and Methylfolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methylfolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Excedrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylfolate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine and folic acid (the active ingredients of Excedrin and Methylfolate, respectively), and Excedrin and Methylfolate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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