Excedrin and Milk thistle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Milk thistle (milk thistle). Common drug interactions include diarrhoea among females and anastomotic complication among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Milk thistle. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

On Jul, 09, 2026

36 people who take Excedrin and Milk thistle together, and have interactions are studied.

Excedrin and Milk thistle drug interactions.

What are the common drug interactions of Excedrin and Milk Thistle, by gender? *:

female:

Diarrhoea
Fatigue (feeling of tiredness)
Anxiety
Anaemia (lack of blood)
Dizziness
Alopecia (absence of hair from areas of the body)
Cystitis (inflammation of the wall of the bladder)
Speech disorder
Therapeutic response unexpected
Abdominal discomfort

male:

Anastomotic complication (complication of surgical connection between two structures)
Back disorder
Rash
Thrombosis (formation of a blood clot inside a blood vessel)
Intestinal stenosis (partial obstruction that causes the centre opening of the intestine to become narrower)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Rectal haemorrhage (bleeding from anus)
Blood pressure increased
Muscular weakness (muscle weakness)

What are the common drug interactions of Excedrin and Milk Thistle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Disturbance in attention
Drug hypersensitivity
Dysgeusia (disorder of the sense of taste)
Dyskinesia (abnormality or impairment of voluntary movement)
Eye movement disorder
Genital burning sensation
Hallucination, visual (seeing things that aren't there)
Kidney infection
Mania (a state of abnormally elevated or irritable mood)

50-59:

Abnormal dreams
Anxiety
Dizziness
Lung neoplasm malignant (cancer tumour of lung)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Swelling face
Therapeutic response unexpected
Anaemia (lack of blood)
Blood glucose increased

60+:

Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Blood albumin decreased
Blood alkaline phosphatase increased
Blood glucose increased
Blood pressure increased
Blood thyroid stimulating hormone increased
C-reactive protein increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis (inflammation of colon)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 27.78%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 27.78%
Nausea (feeling of having an urge to vomit): 6 people, 16.67%
Migraine (headache): 6 people, 16.67%
Pain: 5 people, 13.89%
High Blood Pressure: 3 people, 8.33%
Muscle Spasms (muscle contraction): 3 people, 8.33%
Hypersensitivity: 3 people, 8.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 5.56%
Indigestion: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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