Excedrin and Naltrexone hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Naltrexone hydrochloride (naltrexone hydrochloride). Common drug interactions include surgery among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Naltrexone hydrochloride. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Naltrexone hydrochloride?

Naltrexone hydrochloride has active ingredients of naltrexone hydrochloride. It is often used in alcoholism. eHealthMe is studying from 1,712 Naltrexone hydrochloride users. Check the latest studies of Naltrexone hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

26 people who take Excedrin and Naltrexone hydrochloride together, and have interactions are studied.

Excedrin and Naltrexone hydrochloride drug interactions.

What are the common drug interactions of Excedrin and Naltrexone Hydrochloride, by gender? *:

female:

Surgery
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachyphrenia (abnormally rapid mental activity)
Tinea pedis (a contagious skin infection caused by the ringworm fungus)
Urinary tract infection
Weight increased
Wound dehiscence (a surgical incision reopens either internally or externally)
Arthralgia (joint pain)
Dizziness
Nasopharyngitis (inflammation of the nasopharynx)

male:

Arthralgia (joint pain)
Bone disorder
Haematoma (collection of blood outside the blood vessels)
Impaired healing
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mass
Mobility decreased (ability to move is reduced)
Monoparesis (one limb is very weak, but not completely paralyzed)
Muscle injury
Osteoporotic fracture (fracture due to weak bone)

What are the common drug interactions of Excedrin and Naltrexone Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Bone disorder
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Femur fracture
Fracture delayed union (delayed cure of broken bone)
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Haematoma (collection of blood outside the blood vessels)

40-49:

Abdominal discomfort
Anxiety
Dizziness
Face injury
Fall
Fatigue (feeling of tiredness)
Ligament sprain (ligament stretched)
Loss of consciousness
Memory impairment
Post-traumatic stress disorder

50-59:

Arthralgia (joint pain)
Bone disorder
Femur fracture
Fracture displacement
Fracture nonunion (permanent failure of healing following a broken bone)
Groin pain
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Mobility decreased (ability to move is reduced)
Osteoporotic fracture (fracture due to weak bone)
Pathological fracture (broken bone caused by disease)

60+:

Arthralgia (joint pain)
Back pain
Obstruction
Pelvic pain
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Weight fluctuation
Neck pain
Contusion (a type of hematoma of tissue in which capillaries)
Cough

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 26.92%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 26.92%
Osteoporosis (bones weak and more likely to break): 6 people, 23.08%
Immunodeficiency Common Variable: 6 people, 23.08%
Stress And Anxiety: 2 people, 7.69%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%
Bipolar Disorder (mood disorder): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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