Excedrin and Nifedipine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Nifedipine (nifedipine). Common drug interactions include fatigue among females and abdominal abscess among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Nifedipine. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Nifedipine?

Nifedipine has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 53,459 Nifedipine users. Check the latest studies of Nifedipine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

35 people who take Excedrin and Nifedipine together, and have interactions are studied.

Excedrin and Nifedipine drug interactions.

What are the common drug interactions of Excedrin and Nifedipine, by gender? *:

female:

Fatigue (feeling of tiredness)
Abdominal discomfort
Drug ineffective
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bladder disorder
Blood magnesium decreased
Blood zinc decreased
Cystitis (inflammation of the wall of the bladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Abdominal abscess (collection of pus in abdomen)
Abdominal pain upper
General physical health deterioration (weak health status)
Hepatic steatosis (fatty liver disease)
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestine perforation (hole in large intestine)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Pancreatic pseudocyst (collection of tissue and fluids that forms on pancreas)

What are the common drug interactions of Excedrin and Nifedipine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Dyspnoea (difficult or laboured respiration)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)
Dysstasia (difficulty in standing)
Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

50-59:

Chronic kidney disease
Oesophageal carcinoma (cancer tumour of oesophagus)
Renal failure (kidney dysfunction)

60+:

Abdominal discomfort
Drug ineffective
Drug hypersensitivity
Femur fracture
Micturition urgency (urgency to pass the urine)
Rash macular (small, flat red spots)
Sleep disorder due to a general medical condition
Somnolence (a state of near-sleep, a strong desire for sleep)
Acute circulatory failure (shock)
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 25.71%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 6 people, 17.14%
Pain: 6 people, 17.14%
Gastric Disorder (disease of stomach): 5 people, 14.29%
High Blood Cholesterol: 4 people, 11.43%
Neuropathy Peripheral (surface nerve damage): 4 people, 11.43%
Blood Pressure Abnormal: 4 people, 11.43%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 4 people, 11.43%
Diabetes: 4 people, 11.43%
Inflammation: 4 people, 11.43%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and Nifedipine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously