Excedrin and Promethazine drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Promethazine (promethazine hydrochloride). Common drug interactions include alanine aminotransferase increased among females and chronic kidney disease among males.
The phase IV clinical study analyzes what interactions people have when they take Excedrin and Promethazine. It is created by eHealthMe based on reports of 181 people who take the same drugs from the FDA, and is updated regularly.
What is Excedrin?
Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.
What is Promethazine?
Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.
181 people who take Excedrin and Promethazine together, and have interactions are studied.

What are the common drug interactions of Excedrin and Promethazine, by gender? *
What are the common drug interactions of Excedrin and Promethazine, by age (0-1 to 60+)? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Excedrin and Promethazine?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Excedrin (22,740 reports)
- Promethazine (32,300 reports)
Browse all drug interactions of Excedrin and Promethazine:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Excedrin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Promethazine:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Excedrin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Promethazine and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
- Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine and promethazine hydrochloride (the active ingredients of Excedrin and Promethazine, respectively), and Excedrin and Promethazine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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