Excedrin and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Requip (ropinirole hydrochloride). Common drug interactions include injection site pain among females and therapeutic response unexpected among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Requip. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 21, 2026

64 people who take Excedrin and Requip together, and have interactions are studied.

What are the common drug interactions of Excedrin and Requip, by gender? *:

female:

Injection site pain
Fall
Arthralgia (joint pain)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Depression
Limb crushing injury (crushing injury of upper limb)
Night sweats (sweating in night)
Pruritus generalised (generalized itching)
Malaise (a feeling of general discomfort or uneasiness)
Anogenital warts

male:

Therapeutic response unexpected
Weight decreased
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Fatigue (feeling of tiredness)
Gait disturbance
Ill-defined disorder
Insomnia (sleeplessness)
Malignant melanoma (skin cancer rises from melancytes)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Excedrin and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anogenital warts
Blood hiv rna increased
Kidney infection
Renal failure (kidney dysfunction)
Viral load increased
Anxiety
Depression
Humerus fracture (injury to the upper arm bone)
Multiple fractures
Tooth loss

40-49:

Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Snoring
Speech disorder
Suicidal ideation
Suicide attempt
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary incontinence (inability to control the flow of urine and involuntary urination)

50-59:

Drug ineffective
Injection site pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Fall
Limb crushing injury (crushing injury of upper limb)
Night sweats (sweating in night)
Pruritus generalised (generalized itching)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Staphylococcal infection (an infection with staphylococcus bacteria)
Injection site haemorrhage (bleeding from injection site)

60+:

Drug ineffective
Insomnia (sleeplessness)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Tremor (trembling or shaking movements in one or more parts of your body)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Asthenia (weakness)
Crying
Emotional disorder
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 20.31%
Pain: 10 people, 15.62%
Osteoporosis (bones weak and more likely to break): 9 people, 14.06%
Migraine (headache): 8 people, 12.50%
Muscle Spasms (muscle contraction): 8 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 12.50%
Stress And Anxiety: 7 people, 10.94%
Insomnia (sleeplessness): 7 people, 10.94%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 9.38%
Anaemia (lack of blood): 6 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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