Excedrin and Soma drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Soma (carisoprodol). Common drug interactions include breast mass among females and syncope among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Soma. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

90 people who take Excedrin and Soma together, and have interactions are studied.

What are the common drug interactions of Excedrin and Soma, by gender? *:

female:

Breast mass
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Dyskinesia (abnormality or impairment of voluntary movement)
Emotional distress
Hypertension (high blood pressure)
Injury
Insomnia (sleeplessness)
Kidney infection
Laceration (tearing of soft body tissue)

male:

Syncope (loss of consciousness with an inability to maintain postural tone)
Nausea (feeling of having an urge to vomit)
Blood glucose decreased
Blood glucose increased
Blood pressure decreased
Clavicle fracture
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Fall
Respiratory failure (inadequate gas exchange by the respiratory system)
Rib fracture

What are the common drug interactions of Excedrin and Soma, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
Thyroid cancer
Blood glucose decreased
Blood pressure decreased
Dizziness
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)

30-39:

Anogenital warts
Blood hiv rna increased
Kidney infection
Renal failure (kidney dysfunction)
Viral load increased
Anxiety
Arthralgia (joint pain)
Depression
Fracture
Humerus fracture (injury to the upper arm bone)

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Drug hypersensitivity
Adverse event
Appendix disorder
Bladder dilatation
Bladder disorder
Breast discharge
Breast disorder

50-59:

Disease progression
Hot flush (sudden feelings of heat)
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Non-small cell lung cancer (type of epithelial lung cancer)
Pain in extremity
Thyroid gland cancer
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Abdominal pain upper

60+:

Pneumonia
Rib fracture
Drooling (drop saliva uncontrollably from the mouth)
Drug ineffective
Hypertension (high blood pressure)
Incontinence (lack of moderation or self-control)
Insomnia (sleeplessness)
Irritable bowel syndrome
Myalgia (muscle pain)
Respiration (transport of oxygen from the outside air to the cells within tissues)

What are the existing conditions these people have? *

Migraine (headache): 19 people, 21.11%
Insomnia (sleeplessness): 18 people, 20.00%
Pain: 17 people, 18.89%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 16 people, 17.78%
Back Pain: 13 people, 14.44%
Depression: 10 people, 11.11%
Stress And Anxiety: 8 people, 8.89%
Fatigue (feeling of tiredness): 7 people, 7.78%
Birth Control: 6 people, 6.67%
Acne (skin problems that cause pimples): 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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