Excedrin and Viagra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Viagra (sildenafil citrate). Common drug interactions include device occlusion among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Viagra. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Viagra?

Viagra has active ingredients of sildenafil citrate. It is often used in erection problems. eHealthMe is studying from 63,865 Viagra users. Check the latest studies of Viagra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

56 people who take Excedrin and Viagra together, and have interactions are studied.

What are the common drug interactions of Excedrin and Viagra, by gender? *:

female:

Device occlusion
Diarrhoea
Dizziness
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Ear pain
Eye pain
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)

male:

Drug ineffective
Back pain
Blood glucose increased
Body tinea (ringworm of the body)
Emotional distress
Enterocutaneous fistula
Hepatic steatosis (fatty liver disease)
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestine perforation (hole in large intestine)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))

What are the common drug interactions of Excedrin and Viagra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arterial disorder
Defaecation urgency (a sudden compelling urge to defecate)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematocrit decreased
Haemoglobin decreased

40-49:

Diarrhoea
Difficulty in micturition (difficulty to urinate)
Dizziness
Drug hypersensitivity
Dyspnoea exertional (breathlessness or shortness of breath)
Ear pain
Ejaculation disorder
Eye pain
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)

50-59:

Arthralgia (joint pain)
Back pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Fatigue (feeling of tiredness)
Hiv infection
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neuropathy peripheral (surface nerve damage)
Visual impairment
Abdominal pain upper

60+:

Anxiety
Deafness
Aphasia (damage to the parts of the brain that control language)
Carotid artery stenosis (narrowing of carotid artery)
Cerebral artery stenosis (hardening of brain blood vessels)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Disturbance in attention
Drug maladministration
Eye pain
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)

What are the existing conditions these people have? *

Pain: 7 people, 12.50%
Migraine (headache): 7 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.50%
High Blood Pressure: 7 people, 12.50%
High Blood Cholesterol: 6 people, 10.71%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.93%
Diabetes: 5 people, 8.93%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.14%
Hypersensitivity: 4 people, 7.14%
Type 2 Diabetes: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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