Excedrin and Xolair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Xolair (omalizumab). Common drug interactions include palpitations among females and non-hodgkin's lymphoma among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Xolair. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Xolair?

Xolair has active ingredients of omalizumab. It is often used in asthma. eHealthMe is studying from 77,554 Xolair users. Check the latest studies of Xolair.

On Jul, 15, 2026

44 people who take Excedrin and Xolair together, and have interactions are studied.

What are the common drug interactions of Excedrin and Xolair, by gender? *:

female:

Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pulmonary thrombosis (scarring in the lungs)
Rash
Skin discolouration (change of skin colour)
Anaphylactic reaction (serious allergic reaction)
Malaise (a feeling of general discomfort or uneasiness)
Dyspnoea (difficult or laboured respiration)
Hypersensitivity
Pruritus (severe itching of the skin)

male:

Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Chest discomfort
Hypertension (high blood pressure)
Ill-defined disorder
Influenza
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)
Infusion site rash
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Excedrin and Xolair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Anaphylactic reaction (serious allergic reaction)
Chills (felling of cold)
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Gastric infection (infection of stomach)
Hypersensitivity
Hyperventilation
Malaise (a feeling of general discomfort or uneasiness)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

30-39:

Dyspnoea (difficult or laboured respiration)
Local swelling (swelling at the site of some application of substance or injury)
Localised oedema (fluid retention in a particular part of the body)
Rash

40-49:

Alanine aminotransferase increased
Albumin globulin ratio decreased
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood magnesium decreased
Haemoglobin decreased
Red blood cell count decreased
Chest discomfort
Fatigue (feeling of tiredness)

50-59:

Hypertension (high blood pressure)
Dysphagia (a condition in which swallowing is difficult or painful)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Thrombosis (formation of a blood clot inside a blood vessel)
Arthralgia (joint pain)
Dizziness
Gastrointestinal motility disorder (abnormal intestinal contractions)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)

60+:

Drug ineffective
Abdominal pain upper
Thirst
Weight decreased
Death
Malaise (a feeling of general discomfort or uneasiness)
Back injury
Crying
Hallucination (an experience involving the perception of something not present)
Nerve compression

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 34.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 34.09%
Migraine (headache): 4 people, 9.09%
Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 6.82%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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