Exforge and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exforge (amlodipine besylate; valsartan) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include urinary tract infection among females and renal impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Exforge and Isosorbide dinitrate. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Exforge?

Exforge has active ingredients of amlodipine besylate; valsartan. It is often used in high blood pressure. eHealthMe is studying from 13,350 Exforge users. Check the latest studies of Exforge.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

29 people who take Exforge and Isosorbide dinitrate together, and have interactions are studied.

Exforge and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Exforge and Isosorbide Dinitrate, by gender? *:

female:

Urinary tract infection
Abnormal faeces (abnormal stool)
Acute respiratory failure
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic disorder
Arthralgia (joint pain)
Basophil count increased
Blood glucose increased
Blood magnesium increased
Blood potassium increased

male:

Renal impairment (severely reduced kidney function)
Balance disorder
Back pain
Blood glucose decreased
Cardiac arrest
Decreased appetite
Gait disturbance
Hypotension (abnormally low blood pressure)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Kounis syndrome (the concurrence of heart pain with conditions associated with mast cell activation leads to heart muscle damage)

What are the common drug interactions of Exforge and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease

50-59:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Cardiac arrest
Hepatic steatosis (fatty liver disease)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Hypotension (abnormally low blood pressure)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Kounis syndrome (the concurrence of heart pain with conditions associated with mast cell activation leads to heart muscle damage)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Prinzmetal angina (cardiac chest pain at rest that occurs in cycles)
Urine albumin/creatinine ratio increased

60+:

Oedema peripheral (superficial swelling)
Urinary tract infection
Blood potassium increased
Blood urea increased
Bone callus excessive (excessive bony deposit formed between and around the broken ends of bone fractures)
Contusion (a type of hematoma of tissue in which capillaries)
Femur fracture
Flatulence (flatus expelled through the anus)
Haemoglobin decreased
Injury

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 58.62%
Type 2 Diabetes: 12 people, 41.38%
Arrhythmias (irregular heartbeat): 11 people, 37.93%
Productive Cough: 9 people, 31.03%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 9 people, 31.03%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 9 people, 31.03%
Insomnia (sleeplessness): 9 people, 31.03%
Diabetes: 8 people, 27.59%
Cough: 7 people, 24.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.24%

* Approximation only. Some reports may have incomplete information.

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