Exforge and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exforge (amlodipine besylate; valsartan) and Melatonin (melatonin). Common drug interactions include injection site bruising among females and anxiety disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Exforge and Melatonin. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Exforge?

Exforge has active ingredients of amlodipine besylate; valsartan. It is often used in high blood pressure. eHealthMe is studying from 13,350 Exforge users. Check the latest studies of Exforge.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 04, 2026

42 people who take Exforge and Melatonin together, and have interactions are studied.

Exforge and Melatonin drug interactions.

What are the common drug interactions of Exforge and Melatonin, by gender? *:

female:

Injection site bruising
Injection site erythema (redness at injection site)
Injection site mass
Joint swelling
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oedema peripheral (superficial swelling)
Respiratory tract infection
Stomatitis (inflammation of mucous membrane of mouth)
Teeth brittle (other half has a defect in the teeth)

male:

Anxiety disorder
Depression
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Cerebral haemorrhage (bleeding within the brain)
Leukocytosis (increased white blood cells)
Pain in extremity
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Eye disorder

What are the common drug interactions of Exforge and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Bladder hypertrophy (bladder overgrowth- increase in cell size)
Leukocytosis (increased white blood cells)
Abdominal distension
Abdominal pain
Altered state of consciousness (altered state of mind)
Cholecystitis (infection of gallbladder)
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Gallbladder enlargement
Inflammation
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Fall
Pain in extremity
Cough
Diarrhoea
Dry mouth
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Eye disorder
Facial paralysis (loss of function of face muscle)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 42.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 30.95%
Sleep Disorder: 13 people, 30.95%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 30.95%
Pain: 10 people, 23.81%
Diabetes: 8 people, 19.05%
Depression: 7 people, 16.67%
Constipation: 6 people, 14.29%
Blood Pressure Abnormal: 6 people, 14.29%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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