Exidine and Epipen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exidine (chlorhexidine gluconate) and Epipen (epinephrine). Common drug interactions include iron deficiency among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Exidine and Epipen. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Exidine?

Exidine has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 17,299 Exidine users. Check the latest studies of Exidine.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

On Aug, 01, 2026

70 people who take Exidine and Epipen together, and have interactions are studied.

What are the common drug interactions of Exidine and Epipen, by gender? *:

female:

Iron deficiency
Joint swelling
Muscle atrophy (a decrease in the mass of the muscle)
Muscle disorder (muscle disease)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Onychoclasis (breaking of the nails)
Peripheral swelling
Skin exfoliation (removal of the oldest dead skin cells)

male:

Death
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atrioventricular block (heart block)
Back pain
Blood chloride decreased
Blood creatinine decreased
Blood sodium decreased
Blood urea decreased

What are the common drug interactions of Exidine and Epipen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Diarrhoea
Dehydration (dryness resulting from the removal of water)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mucosal inflammation (infection of mucous membrane)
Pneumonia
Thrombocytopenia (decrease of platelets in blood)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)

10-19:

Death

20-29:

n/a

30-39:

Cardiac arrest
Device failure
Cellulitis (infection under the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Aggression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood potassium decreased
Bone density decreased
Bronchial secretion retention
Cardiac arrest
Decreased appetite
Depression
Emotional distress

50-59:

Migraine (headache)
Stomatitis (inflammation of mucous membrane of mouth)
Swelling
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colonoscopy
Haematuria (presence of blood in urine)
Hospitalisation
Hypersensitivity
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

60+:

Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Bone pain
Cataract (clouding of the lens inside the eye)
Discomfort
Flatulence (flatus expelled through the anus)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal oedema (excessive build-up of fluid in the gastrointestinal tract tissues)
Gastrointestinal pain
Glaucoma (increased fluid pressure in the eye with vision loss)

What are the existing conditions these people have? *

Asthma: 13 people, 18.57%
Hypersensitivity: 12 people, 17.14%
Pain: 8 people, 11.43%
High Blood Pressure: 7 people, 10.00%
High Blood Cholesterol: 7 people, 10.00%
Wound: 6 people, 8.57%
Herpes Zoster: 6 people, 8.57%
Dyspnea (difficult or laboured breathing): 6 people, 8.57%
Fungal Infection: 6 people, 8.57%
Hereditary Angioedema (recurrent episodes of severe swelling): 6 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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