Exidine and Narcan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exidine (chlorhexidine gluconate) and Narcan (naloxone hydrochloride). Common drug interactions include dysfunctional uterine bleeding among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Exidine and Narcan. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Exidine?

Exidine has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 17,299 Exidine users. Check the latest studies of Exidine.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

On Jul, 19, 2026

46 people who take Exidine and Narcan together, and have interactions are studied.

What are the common drug interactions of Exidine and Narcan, by gender? *:

female:

Dysfunctional uterine bleeding
Dyspnoea (difficult or laboured respiration)
Facial pain
Febrile neutropenia (fever with reduced white blood cells)
Fistula (an abnormal connection or passageway between two)
Gastrointestinal obstruction
General physical health deterioration (weak health status)
Gingival erythema (redness of gums)
Gingival swelling (gums swelling)
Granuloma (a small area of inflammation due to tissue injury)

male:

Anxiety
Pain
Bone density decreased
Bone disorder
Chest pain
Colon cancer metastatic (cancer of colon spreads to other part of body)
Compression fracture (fracture due to pressure caused by injury)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Haematuria (presence of blood in urine)
Hypertension (high blood pressure)

What are the common drug interactions of Exidine and Narcan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypotension (abnormally low blood pressure)

20-29:

n/a

30-39:

n/a

40-49:

Pain
Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Haematuria (presence of blood in urine)
Metastases to bone (cancer spreads to bone)
Osteonecrosis of jaw (death of bone of jaw)
Chronic kidney disease
Emotional distress
Osteonecrosis (death of bone)

50-59:

Proteinuria (presence of protein in the urine)
Renal disorder (kidney disease)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Stomatitis (inflammation of mucous membrane of mouth)
Swelling
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Chronic kidney disease
Renal failure (kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Arthralgia (joint pain)
Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Spinal fusion surgery
Vomiting
Wound dehiscence (a surgical incision reopens either internally or externally)
Abdominal pain
Anastomotic leak
Anxiety

What are the existing conditions these people have? *

Pain: 10 people, 21.74%
Metastases To Bone (cancer spreads to bone): 7 people, 15.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.22%
Hiv Infection: 6 people, 13.04%
Stress And Anxiety: 6 people, 13.04%
Nausea (feeling of having an urge to vomit): 5 people, 10.87%
Infection: 5 people, 10.87%
Depression: 5 people, 10.87%
High Blood Pressure: 5 people, 10.87%
Rickets (softening of bones): 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

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