Exparel and Meloxicam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Exparel (bupivacaine) and Meloxicam (meloxicam). Common drug interactions include manipulation among females and arthrofibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Exparel and Meloxicam. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Exparel?

Exparel has active ingredients of bupivacaine. eHealthMe is studying from 1,881 Exparel users. Check the latest studies of Exparel.

What is Meloxicam?

Meloxicam has active ingredients of meloxicam. It is often used in arthritis. eHealthMe is studying from 68,016 Meloxicam users. Check the latest studies of Meloxicam.



On Jul, 18, 2026

17 people who take Exparel and Meloxicam together, and have interactions are studied.

Exparel and Meloxicam drug interactions.

What are the common drug interactions of Exparel and Meloxicam, by gender? *:

female:

  1. Manipulation (the skilful handling, controlling or using of something or someone)
  2. Arthrofibrosis (serious condition that can afflict knee joints that have either been recently injured, operated upon, or both)
  3. Drug ineffective

male:

  1. Arthrofibrosis (serious condition that can afflict knee joints that have either been recently injured, operated upon, or both)
  2. Postoperative wound infection
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Fall
  5. Haemorrhagic anaemia (anaemia due to excessive bleeding)
  6. Manipulation (the skilful handling, controlling or using of something or someone)
  7. Urinary retention postoperative

What are the common drug interactions of Exparel and Meloxicam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Manipulation (the skilful handling, controlling or using of something or someone)

50-59:

  1. Arthrofibrosis (serious condition that can afflict knee joints that have either been recently injured, operated upon, or both)
  2. Drug ineffective
  3. Fall

60+:

  1. Manipulation (the skilful handling, controlling or using of something or someone)
  2. Postoperative wound infection
  3. Arthrofibrosis (serious condition that can afflict knee joints that have either been recently injured, operated upon, or both)
  4. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  5. Haemorrhagic anaemia (anaemia due to excessive bleeding)
  6. Urinary retention postoperative

What are the existing conditions these people have? *

  1. Nerve Block (the interruption of signals travelling along a nerve): 4 people, 23.53%
  2. High Blood Pressure: 2 people, 11.76%
  3. Procedural Pain: 2 people, 11.76%
  4. Breakthrough Pain: 2 people, 11.76%
  5. Gout (uric acid crystals building up in the body): 2 people, 11.76%
  6. Vitamin B12 Deficiency: 1 person, 5.88%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%
  8. Cough: 1 person, 5.88%
  9. Dyspnea (difficult or laboured breathing): 1 person, 5.88%
  10. Enlarged Prostate: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Exparel and Meloxicam?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Exparel and Meloxicam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Exparel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Meloxicam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Exparel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Meloxicam and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on bupivacaine and meloxicam (the active ingredients of Exparel and Meloxicam, respectively), and Exparel and Meloxicam (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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