Extraneal and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Extraneal (icodextrin) and Lactulose (lactulose). Common drug interactions include skin burning sensation among females and peritonitis among males.

The phase IV clinical study analyzes what interactions people have when they take Extraneal and Lactulose. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Extraneal?

Extraneal has active ingredients of icodextrin. eHealthMe is studying from 32,994 Extraneal users. Check the latest studies of Extraneal.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 12, 2026

61 people who take Extraneal and Lactulose together, and have interactions are studied.

Extraneal and Lactulose drug interactions.

What are the common drug interactions of Extraneal and Lactulose, by gender? *:

female:

Skin burning sensation
Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Death
Malaise (a feeling of general discomfort or uneasiness)
Cardiac arrest
Abdominal pain
Circulatory collapse
Peritoneal haemorrhage (peritoneal bleeding)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)

male:

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Abdominal distension
General physical health deterioration (weak health status)
Hip fracture
Hypokalaemia (low potassium)
Blood albumin decreased
Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Arthralgia (joint pain)
Drug hypersensitivity

What are the common drug interactions of Extraneal and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)
Catheter site haemorrhage (bleeding at catheter site)
Chest discomfort
Chills (felling of cold)
Dizziness
Abdominal pain
Bloody peritoneal effluent
Muscle haemorrhage (bleeding in muscle)
Soft tissue injury

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)

40-49:

Abdominal distension
Diarrhoea
Anxiety
Body temperature fluctuation
Deformity (disfigurement)
Drug hypersensitivity
Eczema asteatotic (severe dry skin- during the winter months and in the elderly)
Hyperkeratosis (thickening of the outer layer of the skin)
Leukocytosis (increased white blood cells)
Nail ridging (nail has raised ridges and is thin and curved inward)

50-59:

Hypotension (abnormally low blood pressure)
Peritoneal haemorrhage (peritoneal bleeding)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Thrombocytopenia (decrease of platelets in blood)
Type 2 diabetes mellitus
Vomiting
Abdominal pain upper
Intestinal ulcer perforation (holes in intestine wall due to intestinal ulcer)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Peritoneal dialysis complication

60+:

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Death
Blood albumin decreased
Cardiac arrest
Sepsis (a severe blood infection that can lead to organ failure and death)
Arthralgia (joint pain)
Endocarditis (inflammation in heart muscle)
Fall
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Chronic Renal Failure (kidney failure): 8 people, 13.11%
Asthma: 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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