Eylea and Coumadin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eylea (aflibercept) and Coumadin (warfarin sodium). Common drug interactions include iritis among females and blindness among males.

The phase IV clinical study analyzes what interactions people have when they take Eylea and Coumadin. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

On Jul, 04, 2026

66 people who take Eylea and Coumadin together, and have interactions are studied.

What are the common drug interactions of Eylea and Coumadin, by gender? *:

female:

Iritis (painful inflammation of the iris of the eye)
Visual acuity reduced (reduced clearness of vision)
Eye inflammation
Vision blurred
Anxiety
Disease progression
Drug ineffective
Eye haemorrhage (bleeding in the eye)
Eye pain
International normalised ratio increased

male:

Blindness
Blindness unilateral
Optic disc haemorrhage (bleeding from optic disc)
Retinal artery occlusion (blockage of retinal artery)
Vision blurred
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Angiopathy (generic term for a disease of the blood vessels)
Dyspnoea (difficult or laboured respiration)
Eye haemorrhage (bleeding in the eye)
Haemoglobin decreased

What are the common drug interactions of Eylea and Coumadin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Visual acuity reduced (reduced clearness of vision)
Eye inflammation
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Anxiety
Blindness
Blindness unilateral
Corneal decompensation (disorder of the hydration of the cornea which can lead to corneal swelling)
Corneal endotheliitis (an immune response within the endothelium in blood vessels)

What are the existing conditions these people have? *

Age-Related Macular Degeneration: 14 people, 21.21%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 8 people, 12.12%
Choroidal Neovascularisation (creation of new blood vessels in vascular layer of eye): 8 people, 12.12%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 12.12%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 6 people, 9.09%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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