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Eylea and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eylea (aflibercept) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include eosinophil count increased among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Eylea and Spiriva. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

On Jul, 27, 2026

69 people who take Eylea and Spiriva together, and have interactions are studied.

Eylea and Spiriva drug interactions.

What are the common drug interactions of Eylea and Spiriva, by gender? *:

female:

  1. Eosinophil count increased
  2. Pulmonary function test decreased
  3. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  4. Dyspnoea (difficult or laboured respiration)
  5. Asthenia (weakness)
  6. Breast cancer
  7. Drug ineffective
  8. Tooth fracture
  9. Visual impairment
  10. Abdominal pain

male:

  1. Rash
  2. Death
  3. Tremor (trembling or shaking movements in one or more parts of your body)
  4. Arthralgia (joint pain)
  5. Blindness transient (sudden loss of vision)
  6. Drug hypersensitivity
  7. Gout (uric acid crystals building up in the body)
  8. Parainfluenzae virus infection
  9. Pneumonia
  10. Sinusitis (inflammation of sinus)

What are the common drug interactions of Eylea and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Asthenia (weakness)
  2. Breast cancer
  3. Aphonia (inability to produce voice)
  4. Arthralgia (joint pain)
  5. Blindness transient (sudden loss of vision)
  6. Blood cholesterol increased
  7. Bronchial hyperreactivity
  8. Bronchial secretion retention
  9. Chest discomfort
  10. Confusional state

What are the existing conditions these people have? *

  1. Spinal Column Stenosis (narrowing of spinal column): 9 people, 13.04%
  2. Age-Related Macular Degeneration: 7 people, 10.14%
  3. Choroidal Neovascularisation (creation of new blood vessels in vascular layer of eye): 5 people, 7.25%
  4. Asthma: 5 people, 7.25%
  5. Multiple Myeloma (cancer of the plasma cells): 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

Do you take Eylea and Spiriva?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Eylea and Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Eylea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Eylea and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spiriva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on aflibercept and tiotropium bromide monohydrate (the active ingredients of Eylea and Spiriva, respectively), and Eylea and Spiriva (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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