Fanapt and Saphris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fanapt (iloperidone) and Saphris (asenapine maleate). Common drug interactions include insomnia among females and eating disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Fanapt and Saphris. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Fanapt?

Fanapt has active ingredients of iloperidone. It is often used in schizophrenia. eHealthMe is studying from 1,443 Fanapt users. Check the latest studies of Fanapt.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

41 people who take Fanapt and Saphris together, and have interactions are studied.

What are the common drug interactions of Fanapt and Saphris, by gender? *:

female:

Insomnia (sleeplessness)
Weight increased
Abnormal behaviour
Depression
Dyspnoea (difficult or laboured respiration)
Heart rate increased
Hunger
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Periodic limb movement disorder
Sleep paralysis (waking up and unable to move or speak)

male:

Eating disorder
Acne (skin problems that cause pimples)
Pulmonary embolism (blockage of the main artery of the lung)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased
Acute respiratory failure
Aggression
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Blood pressure systolic increased
Coma (state of unconsciousness lasting more than six hours)

What are the common drug interactions of Fanapt and Saphris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Lactation disorder

20-29:

Acne (skin problems that cause pimples)
Eating disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Toothache (tooth pain)
Headache (pain in head)
Aggression
Insomnia (sleeplessness)
Oral pain
Stomatitis (inflammation of mucous membrane of mouth)
Influenza

30-39:

Arthralgia (joint pain)
Compulsive shopping
Eating disorder
Hospitalisation
Nephrolithiasis (calculi in the kidneys)
Weight increased
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Pulmonary embolism (blockage of the main artery of the lung)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

40-49:

Tardive dyskinesia (a disorder that involves involuntary movements)
Neoplasm malignant (cancer tumour)
Suicidal ideation
Drug effect decreased
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Dystonia (abnormal muscle tone)
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Fatigue (feeling of tiredness)
Heart rate increased
Hunger
Insomnia (sleeplessness)
Merycism (a rare disease in which food is chewed, swallowed, and then returned to the mouth and chewed again)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Periodic limb movement disorder
Pseudodementia (severe form of depression that results from a progressive brain disorder in which cognitive changes mimic those of dementia)

60+:

Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 10 people, 24.39%
Depression: 10 people, 24.39%
Stress And Anxiety: 9 people, 21.95%
Pain: 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 6 people, 14.63%
Insomnia (sleeplessness): 6 people, 14.63%
High Blood Cholesterol: 6 people, 14.63%
Affective Disorder (mental disorder): 5 people, 12.20%
Fever: 4 people, 9.76%
Dyspnea (difficult or laboured breathing): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

Do you take Fanapt and Saphris?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously