Febuxostat and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Febuxostat (febuxostat) and Senna (senna). Common drug interactions include varicose vein among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Febuxostat and Senna. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Febuxostat?

Febuxostat has active ingredients of febuxostat. eHealthMe is studying from 9,693 Febuxostat users. Check the latest studies of Febuxostat.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

On Jul, 21, 2026

73 people who take Febuxostat and Senna together, and have interactions are studied.

What are the common drug interactions of Febuxostat and Senna, by gender? *:

female:

Varicose vein (veins that have become enlarged and tortuous)
Vitamin d deficiency
Weight increased
Platelet count decreased
Bacterial sepsis
Blood pressure increased
Cardiac failure
Cardiac failure chronic
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)

male:

Cardiac failure
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Dyspnoea (difficult or laboured respiration)
Oedema (fluid collection in tissue)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Myositis (inflammation of the muscles)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Febuxostat and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastrointestinal perforation (hole in the digestive tract)

50-59:

Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Tremor (trembling or shaking movements in one or more parts of your body)
Myositis (inflammation of the muscles)
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Gout (uric acid crystals building up in the body)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypokalaemia (low potassium)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Oedema peripheral (superficial swelling)
Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Pneumonia
Abdominal pain
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 17.81%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 12 people, 16.44%
Gout (uric acid crystals building up in the body): 10 people, 13.70%
Multiple Myeloma (cancer of the plasma cells): 8 people, 10.96%
Pain: 7 people, 9.59%
Hereditary Angioedema (recurrent episodes of severe swelling): 7 people, 9.59%
Nausea (feeling of having an urge to vomit): 6 people, 8.22%
Cardiac Failure: 6 people, 8.22%
High Blood Cholesterol: 5 people, 6.85%
Fever: 5 people, 6.85%

* Approximation only. Some reports may have incomplete information.

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