Femara and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Femara (letrozole) and Codeine (codeine sulfate). Common drug interactions include metastases to liver among females and altered state of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Femara and Codeine. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Femara?

Femara has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 19,630 Femara users. Check the latest studies of Femara.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 30, 2026

49 people who take Femara and Codeine together, and have interactions are studied.

What are the common drug interactions of Femara and Codeine, by gender? *:

female:

Metastases to liver (cancer spreads to liver)
Muscular weakness (muscle weakness)
Pain in extremity
Spinal osteoarthritis (joint cartilage loss in spine)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Disease progression
Facet joint syndrome (problem with movement of the facet joints of the spine)
Groin pain
Hypertension (high blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)

male:

Altered state of consciousness (altered state of mind)
Anaemia (lack of blood)
Dental caries
Fatigue (feeling of tiredness)
Gait disturbance
Hypertension (high blood pressure)
Impaired healing
Injury
Leukopenia (less number of white blood cells in blood)
Lymphadenopathy (disease or enlargement of lymph nodes)

What are the common drug interactions of Femara and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Vomiting
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bone disorder
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Foot fracture
Metastases to bone (cancer spreads to bone)
Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

50-59:

Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)
Stomatitis (inflammation of mucous membrane of mouth)
Swelling face
Syncope (loss of consciousness with an inability to maintain postural tone)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Tooth loss
Trismus (reduced opening of the jaws)
Uterine prolapse

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Metastases to bone (cancer spreads to bone)
Pyrexia (fever)
Vertigo
Abdominal discomfort
Abdominal distension
Abdominal mass (localized enlargement or swelling in the human abdomen)
Anorectal discomfort
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 22 people, 44.90%
Metastases To Bone (cancer spreads to bone): 19 people, 38.78%
Nausea (feeling of having an urge to vomit): 16 people, 32.65%
Diarrhea: 13 people, 26.53%
Fever: 11 people, 22.45%
Back Pain: 10 people, 20.41%
Bone Loss: 10 people, 20.41%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 10 people, 20.41%
Anaemia (lack of blood): 8 people, 16.33%
Lymphoedema (localized fluid retention and tissue swelling): 8 people, 16.33%

* Approximation only. Some reports may have incomplete information.

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